Figure 3From: Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumorsUpregulation of β-catenin and anti-apoptotic protein Mcl-1 in response to OPN in GIST cell lines resistant to imatinib. (A) Western blotting analysis of GIST48B and GIST62 cell lines treated with imatinib (1 μM) or OPN (2 μg/mL). (B) Quantification of the western blots showing significant changes in the expression of β-catenin and anti-apoptotic protein Mcl-1 in relation to OPN administration in GIST48B and GIST62 (Columns, mean of results in triplicate; bars, SD. *, P <0.05).Back to article page