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Table 4 Cox proportional hazard regression analyses for overall survival in young patients with large hepatocellular carcinoma after hepatectomy

From: Liver resection for young patients with large hepatocellular carcinoma: a single center experience from China

Variables n* Univariateanalysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Gender      
 Female 17 1   1  
 Male 53 0.752(0.290-3.547) 0.548 0.721(0.309-3.176) 0.408
Hepatitis B status      
 Positive 61 1   1  
 Negative 9 0.963(0.243-4.416) 0.363 0.904(0.262-3.455) 0.789
AFP level (ng/mL)      
 Negative 21 1   1  
 Positive 49 1.006(0.561-1.012) 0.053 1.069(0.972-1.108) 0.129
Number of tumors      
 Single 49 1   1  
 Multiple 21 1.351(0.739-2.146) 0.053 1.683(0.460-2.373) 0.112
Liver cirrhosis      
 Absent 38 1   1  
 Present 32 1.114(1.058-2.934) 0.045 1.137(0.866-2.798) 0.207
Child-Pugh classification      
 A 56 1   1  
 B 14 1.237(0.762-2.387) 0.508 1.119(0.428-3.946) 0.623
Vascular invasion      
 Absent 37 1   1  
 Present 33 2.112(1.037-3.896) 0.017 2.233(1.010-4.232) 0.031
Edmondson-Steiner grade      
 Low grade (I and II) 34 1   1  
 High grade (III and IV) 36 1.560(1.087-3.331) 0.036 1.747(1.235-3.346) 0.042
Surgical resection margin      
 ≤1 cm 34 1   1  
 >1 cm 36 1.339(0.234-3.642) 0.743 1.366(0.356-2.956) 0.375
Blood loss (ml)      
 <1,000 36 1   1  
 ≥1,000 34 1.036(0.424-2.986) 0.117 1.352(0.374-3.463) 0.353
Blood transfusion (ml)      
 Without 32 1   1  
 With 38 1.008(0.532-1.787) 0.733 1.453(0.834-2.564) 0.656
Complications      
 Absent 54 1   1  
 Present 16 0.986(0.330-2.675) 0.559 0.824(0.363-2.863) 0.348
BMI      
 Normal weight 55 1   1  
 Overweight/obese 15 1.006(0.687-1.331) 0.309 1.250(0.909-1.671) 0.326
  1. *Number of patients. P values shown in bold indicate statistical significance between groups. AFP, alpha-fetoprotein; BMI, body mass index; HR, hazard ratio.