Table 4 Cox proportional hazard regression analyses for overall survival in young patients with large hepatocellular carcinoma after hepatectomy
Variables | n* | Univariateanalysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | ||
Gender | |||||
Female | 17 | 1 | 1 | ||
Male | 53 | 0.752(0.290-3.547) | 0.548 | 0.721(0.309-3.176) | 0.408 |
Hepatitis B status | |||||
Positive | 61 | 1 | 1 | ||
Negative | 9 | 0.963(0.243-4.416) | 0.363 | 0.904(0.262-3.455) | 0.789 |
AFP level (ng/mL) | |||||
Negative | 21 | 1 | 1 | ||
Positive | 49 | 1.006(0.561-1.012) | 0.053 | 1.069(0.972-1.108) | 0.129 |
Number of tumors | |||||
Single | 49 | 1 | 1 | ||
Multiple | 21 | 1.351(0.739-2.146) | 0.053 | 1.683(0.460-2.373) | 0.112 |
Liver cirrhosis | |||||
Absent | 38 | 1 | 1 | ||
Present | 32 | 1.114(1.058-2.934) | 0.045 | 1.137(0.866-2.798) | 0.207 |
Child-Pugh classification | |||||
A | 56 | 1 | 1 | ||
B | 14 | 1.237(0.762-2.387) | 0.508 | 1.119(0.428-3.946) | 0.623 |
Vascular invasion | |||||
Absent | 37 | 1 | 1 | ||
Present | 33 | 2.112(1.037-3.896) | 0.017 | 2.233(1.010-4.232) | 0.031 |
Edmondson-Steiner grade | |||||
Low grade (I and II) | 34 | 1 | 1 | ||
High grade (III and IV) | 36 | 1.560(1.087-3.331) | 0.036 | 1.747(1.235-3.346) | 0.042 |
Surgical resection margin | |||||
≤1 cm | 34 | 1 | 1 | ||
>1 cm | 36 | 1.339(0.234-3.642) | 0.743 | 1.366(0.356-2.956) | 0.375 |
Blood loss (ml) | |||||
<1,000 | 36 | 1 | 1 | ||
≥1,000 | 34 | 1.036(0.424-2.986) | 0.117 | 1.352(0.374-3.463) | 0.353 |
Blood transfusion (ml) | |||||
Without | 32 | 1 | 1 | ||
With | 38 | 1.008(0.532-1.787) | 0.733 | 1.453(0.834-2.564) | 0.656 |
Complications | |||||
Absent | 54 | 1 | 1 | ||
Present | 16 | 0.986(0.330-2.675) | 0.559 | 0.824(0.363-2.863) | 0.348 |
BMI | |||||
Normal weight | 55 | 1 | 1 | ||
Overweight/obese | 15 | 1.006(0.687-1.331) | 0.309 | 1.250(0.909-1.671) | 0.326 |