Figure 2From: Response of an aggressive periosteal aneurysmal bone cyst (ABC) of the radius to denosumab therapyHistopathology of the pre- and post-treatment tumor tissue specimen. (A) Pre-treatment biopsy sample showing giant cell containing soft tissue mass with extensive infiltration of the skeletal muscle (H&E stain; original magnification 50×). (B) Abundant lesional giant cells with numerous nuclei and mononuclear cells in the background (H&E stain; original magnification 100×). Inset shows immunohistochemical expression of RANK (dilution 1:400; R&D Systems, Abingdon, United Kingdom) by the osteoclastic giant cells. (C) Denosumab treatment induced boney containment (asterisk) of the tumor (upper left) (H&E stain; original magnification 25×). (D) Post-denosumab-treatment tumor specimen showing pronounced reduction of the number of giant cells (H&E stain; original magnification 100×).Back to article page