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Table 2 Univariate analysis of patient survival according to clinicopathologic characteristics

From: Correlation of survival and EGFR mutation with predominant histologic subtype according to the new lung adenocarcinoma classification in stage IB patients

 

5-year DFS rate (%)

P

5-year OS rate (%)

P

Gender

 

0.313

 

0.601

 Male (n = 79)

53.4

 

60.7

 

 Female (n = 57)

51.7

 

66.7

 

Age (years)

 

0.643

 

0.475

 <65 (n = 95)

50.1

 

59.7

 

 ≥65 (n = 41)

56.8

 

67.2

 

Smoking status

 

0.541

 

0.312

 Never (n = 103)

56.5

 

70.6

 

 Former or current (n = 33)

46.5

 

54.5

 

Tumor size

 

0.214

 

0.295

 >3 cm (n = 89)

46.7

 

59.7

 

 ≤3 cm (n = 43)

54.2

 

66.2

 

Adjuvant chemotherapy

 

0.213

 

0.713

 Yes (n = 37)

59.1

 

67.9

 

 No (n = 99)

49.0

 

60.3

 

Grade

 

0.675

 

0.233

 Well (n = 57)

59.6

 

73.3

 

 Moderate or poor (n = 79)

50.1

 

55.4

 

Pleural involvement

 

0.769

 

0.961

 Yes (n = 69)

49.0

 

60.4

 

 No (n = 67)

55.2

 

67.5

 

Lymphatic and/or vessel invasion

 

0.045

 

0.112

 Yes (n = 12)

39.1

 

51.7

 

 No (n = 124)

54.3

 

68.1

 

Histological subtypes (IASLC/ATS/ERS)

    

Lepidicpredominant

 

0.042

 

0.307

 Yes (n = 21)

75.2

 

80.8

 

 No (n = 115)

50.8

 

59.3

 

Acinarpredominant

 

0.782

 

0.443

 Yes (n = 39)

55..5

 

67.8

 

 No (n = 97)

49.0

 

58.9

 

Papillary predominant

 

0.401

 

0.405

 Yes (n = 38)

57.6

 

72.1

 

 No (n = 98)

47.1

 

57.2

 

Micropapillary predominant

 

0.041

 

0.175

 Yes (n = 22)

28.4

 

43.5

 

 No (n = 114)

61.1.

 

62.9

 

Solid predominant

 

0.049

 

0.211

 Yes (n = 14)

36.7

 

45.9

 

 No (n = 122)

57.7

 

65.1

 

Variants of invasive adenocarcinoma

0.315

 

0.306

 Yes (n = 2)

100

 

100

 

 No (n = 134)

51.3

 

60.5

 
  1. DFS, disease-free survival rate; OS, overall survival rate.