Inferior oncological prognosis of surgery without oral chemotherapy for stage III colon cancer in clinical settings

Table 2 Univariate and multivariate regression analysis for relapse-free survival (RFS) of stage III colon cancer

Variable	Comparison	Univariate	Multivariate
Variable	Comparison	P value	HR	95% CI	P value
Gender	Female versus male	0.24
Age		0.001	1.01	0.986 to 1.043	0.324
Comorbidity	No versus yes	0.745
ASA (grade ≥3)	No versus yes	0.008	1.000	0.505 to 1.98	0.999
Location	Right versus left side of colon	0.306
	Colon versus rectosigmoid	0.406
Serum CEA	<5 versus ≥5	0.074	0.84	0.519 to 1.366	0.49
Operation	Laparoscopic versus open surgery	0.082	1.01	0.597 to 1.700	0.98
Tumor depth	T1, 2 versus T3, 4	0.002	0.26	0.089 to 0.733	0.01
Lymph node metastasis	N1 (1 to 3) versus N2 (4<)	0.004	0.71	0.387 to 1.301	0.27
TNM stage	IIIA, B versus IIIC	<0.0001	0.4	0.204 to 0.797	0.01
Adjuvant chemotherapy	No versus yes	<0.0001	2.65	1.48 to 4.756	0.001

ASA, American Society of Anesthesiologists physical status classification system; CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio; TNM, tumor, node, metastasis.

ISSN: 1477-7819