Lower skeletal muscle index and early complications in patients undergoing radical cystectomy for bladder cancer

Table 3 Univariate and multivariate analysis for evaluation of the associations between tested parameters and short-term complications

Category	Variables	Overall						Severe (grade ≥3)
		Univariate			Multivariate			Univariate			Multivariate
		OR	(95% CI)	P value	OR	(95% CI)	P value	OR	(95% CI)	P value	OR	(95% CI)	P value
Clinical	Gender^a	0.809	(0.408 to 1.606)	0.545				0.538	(0.120 to 2.407)	0.417
	Age^a	1.153	(0.698 to 1.904)	0.578				3.316	(1.068 to 10.298)	0.038	3.376	(1.074 to 10.614)	0.037
	BMI	0.963	(0.887 to 1.044)	0.358				1.012	(0.876 to 1.170)	0.869
	CCI^a	1.528	(0.886 to 2.636)	0.128				0.891	(0.332 to 2.394)	0.802
	ECOG	1.028	(0.468 to 2.257)	0.946				0.746	(0.205 to 2.714)	0.657
Nutritional	Alb^a	2.780	(1.041 to 7.424)	0.041	3.628	(1.196 to 11.002)	0.023	1.942	(0.247 to 15.237)	0.528
	Preoperative Hb^a	1.912	(0.622 to 5.876)	0.258				1.221	(0.152 to 9.819)	0.851
	Cr^a	0.974	(0.406 to 2.337)	0.952				0.488	(0.062 to 3.822)	0.495
	SMI	0.977	(0.955 to 1.000)	0.045	0.979	(0.954 to 1.004)	0.105	0.951	(0.916 to 0.987)	0.008	0.952	(0.915 to 0.991)	0.017
Tumor specific	AJCC^a	1.304	(1.004 to 1.693)	0.047	1.289	(0.986 to 1.685)	0.063	0.861	(0.334 to 2.220)	0.758
Tumor specific	Grade	1.372	(0.577 to 3.258)	0.474				2.157	(0.276 to 16.854)	0.464
Surgical specific	Diversion^a	0.871	(0.518 to 1.466)	0.604				1.054	(0.409 to 2.272)	0.913
Surgical specific	OT	0.980	(0.760 to 1.263)	0.876				0.826	(0.530 to 1.287)	0.397

^aCategory variables: male patients versus female patients; diversion: orthotopic neobladder versus non-orthotopic neobladder; cut points are indicated as follows: age >70; preoperative Hb female patients <110 g/L or male patients <120 g/L; Alb <35 g/L; creatine (Cr) >110; AJCC >2 or otherwise, CCI > 7.
AJCC American Joint Committee on Cancer, Alb albumin, BMI body mass index, CCI Charlson Comobidity Index, Cr creatine, ECOG Eastern Cooperative Oncology Group, Hb hemoglobin, OT operation time (h), SMI skeletal muscle index.

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