Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast

Table 3 TMEM16A, FADD, and PPFIA1 expressions in invasive ductal carcinoma in relation to clinicopathological parameters (n = number of cases)

	TMEM16A			FADD			PPFIA1			Hazard score^c
	+	-	P	+	-	P	+	-	P	< 2	≥ 2	P
T stage			0.284			0.046^d			0.444			0.069
1	22	1		19	4		22	1		20	3
2 to 3	64	11		43	32		66	9		50	25
N stage			0.756			0.277			1			0.316
0	37	4		29	12		37	4		32	9
1 to 3	49	8		33	24		51	6		38	19
Grade			0.756			0.285			1			0.197
1 to 2	48	8		38	18		50	6		43	13
3	36	4		22	18		36	4		25	15
ER			0.724			0.576			0.439			1.000
0	22	4		15	11		22	4		19	7
1	56	7		42	21		58	5		45	18
PR			0.266			1.000			0.244			0.898
0	19	5		15	9		20	4		18	6
1 to 3	59	6		42	23		60	5		46	19
HER2			1.000			0.918			1.000			0.831
0	46	7		33	20		47	6		37	16
1 to 3	31	4		23	12		32	3		26	9
Age			0.758			1.000			0.723			0.453
< 50	51	8		37	22		54	5		40	19
≥ 50	35	4		25	14		34	5		30	9
LVI^a			1.000			0.746			0.716			0.564
0	26	3		17	12		27	2		19	10
1 to 2	58	7		42	23		58	7		48	17
PNI^b			0.682			0.077			0.678			0.022^a
0	62	9		48	23		63	8		16	55
1	18	1		8	11		18	1		10	9

^aLymphatic vessel invasion.
^bPerineural invasion.
^cHazard score = TMEM16A score + PPFIA1 score – FADD score.
^dP < 0.05.
ER, estrogen receptor; HER2, human epidermal growth factor; PR, progesterone receptor.

ISSN: 1477-7819