Skip to main content

Table 4 Results from Cox regression analysis of resection margins and other factors affecting overall survival in 253 patients after primary resection for colorectal liver metastases

From: Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival

 

Overall survival

Univariate

Multivariate

Variable

n

HR

95% CI

P

HR

95% CI

P

Age/10 y

253

1.32

(1.12, 1.54)

<0.001

1.29

(1.08, 1.54)

0.005

DFI, months

253

0.91

(0.80, 1,03)

0.122

0.91

(0.79, 1.05)

0.187

Number of metastases

253

1.19

(1.10, 1.28)

<0.001

1.31

(1.17, 1.45)

<0.001

Metastasis diam, cm

242

1.11

(1.03, 1.19)

0.006

1.09

(1.02, 1.18)

0.023

RM status  R0

205

1.00

Reference

 

1.00

Reference

 

      R1

48

1.69

(1.14, 2.51)

0.014

1.53

(0.98, 2.39)

0.067

T stage

   

0.931

  

0.897

      T2

25

1.00

Reference

 

1.00

Reference

 

      T3

180

1.10

(0.65, 1.87)

 

0.99

(0.54, 1.81)

 

      T4

34

1.11

(0.57, 2.19)

 

0.88

(0.40, 1.90)

 

N stage

   

0.506

  

0.229

      N0

91

1.00

Reference

 

1.00

Reference

 

      N1

103

1.19

(0.83, 1.72)

 

1.32

(0.88, 1.98)

 

      N2

51

1.27

(0.81, 1.98)

 

1.49

(0.92, 2.42)

 

ASA score

253

1.62

(1.20, 2.19)

0.002

1.61

(1.13, 2.29)

0.009

Bilobar   No

159

1.00

Reference

 

1.00

Reference

 

      Yes

94

1.38

(1.01, 1.89)

0.048

1.22

(0.80, 1.86)

0.353

Re-resections

 

0.78

(0.60, 1.01)

0.045

0.71

(0.52, 0.97)

0.016

  1. HR, hazard ratio; CI, confidence interval; DFI, disease-free interval (time between resection of the primary tumor in the colon or rectum and the detection of hepatic metastases); RM, resection margin; T and N stage, analysis of primary tumor in colon or rectum; ASA, American Society of Anesthesiologists. Unknown T-stage n = 14, unknown N-stage: n = 8, unknown diameter of metastases: n =11.
Back to article page

World Journal of Surgical Oncology

ISSN: 1477-7819

Contact us