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Table 4 Results from Cox regression analysis of resection margins and other factors affecting overall survival in 253 patients after primary resection for colorectal liver metastases

From: Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival

  Overall survival
Univariate Multivariate
Variable n HR 95% CI P HR 95% CI P
Age/10 y 253 1.32 (1.12, 1.54) <0.001 1.29 (1.08, 1.54) 0.005
DFI, months 253 0.91 (0.80, 1,03) 0.122 0.91 (0.79, 1.05) 0.187
Number of metastases 253 1.19 (1.10, 1.28) <0.001 1.31 (1.17, 1.45) <0.001
Metastasis diam, cm 242 1.11 (1.03, 1.19) 0.006 1.09 (1.02, 1.18) 0.023
RM status  R0 205 1.00 Reference   1.00 Reference  
      R1 48 1.69 (1.14, 2.51) 0.014 1.53 (0.98, 2.39) 0.067
T stage     0.931    0.897
      T2 25 1.00 Reference   1.00 Reference  
      T3 180 1.10 (0.65, 1.87)   0.99 (0.54, 1.81)  
      T4 34 1.11 (0.57, 2.19)   0.88 (0.40, 1.90)  
N stage     0.506    0.229
      N0 91 1.00 Reference   1.00 Reference  
      N1 103 1.19 (0.83, 1.72)   1.32 (0.88, 1.98)  
      N2 51 1.27 (0.81, 1.98)   1.49 (0.92, 2.42)  
ASA score 253 1.62 (1.20, 2.19) 0.002 1.61 (1.13, 2.29) 0.009
Bilobar   No 159 1.00 Reference   1.00 Reference  
      Yes 94 1.38 (1.01, 1.89) 0.048 1.22 (0.80, 1.86) 0.353
Re-resections   0.78 (0.60, 1.01) 0.045 0.71 (0.52, 0.97) 0.016
  1. HR, hazard ratio; CI, confidence interval; DFI, disease-free interval (time between resection of the primary tumor in the colon or rectum and the detection of hepatic metastases); RM, resection margin; T and N stage, analysis of primary tumor in colon or rectum; ASA, American Society of Anesthesiologists. Unknown T-stage n = 14, unknown N-stage: n = 8, unknown diameter of metastases: n =11.