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Table 5 Risk factors for tumor recurrence in HCC patients with portal vein invasion by univariate analysis

From: C-reactive protein may be a prognostic factor in hepatocellular carcinoma with malignant portal vein invasion

Variables Hazard ratio 95% confidence interval P value
Gender - Female 0.657 0.313–1.376 0.265
Age 0.973 0.946–1.000 0.052
AFP 1.000 1.000–1.000 0.005
PIVKA-II 1.001 1.000–1.001 0.128
Locoregional therapy 1.495 0.848–2.634 0.165
White blood cells 0.961 0.835–1.107 0.582
Hemoglobin 1.010 0.853–1.195 0.909
Platelet counts 1.000 0.998–1.003 0.821
INR 6.056 0.254–144.219 0.266
Albumin 0.533 0.290–0.980 0.043
Total bilirubin 1.047 0.654–1.676 0.849
AST 1.005 0.999–1.011 0.103
ALT 1.002 0.996–1.008 0.565
ALP 1.002 0.995–1.008 0.643
Creatinine 0.427 0.091–2.004 0.281
Estimated GFR 1.015 0.997–1.033 0.102
GGT 1.000 0.998–1.001 0.739
CRP 1.133 1.028–1.249 0.012
Operation (non-anatomical) 1.473 0.863–2.515 0.156
Hepatectomy (minor) 0.922 0.367–2.315 0.863
Maximum tumor size 1.003 0.997–1.010 0.282
Grade (3 and 4) 0.627 0.311–1.267 0.194
Cirrhosis 1.426 0.879–2.314 0.150
Capsule formation 1.020 0.353–2.941 0.971
Capsular invasion 0.715 0.439–1.165 0.178
Bile duct invasion 0.752 0.302–1.873 0.540
Serosa involvement 5.863 1.372–25.058 0.017
Intrahepatic metastasis 1.787 1.098–2.910 0.020
Multicentric occurrence 0.048 0.00–195.191 0.474
Margin (mm) 1.006 0.986–1.026 0.566
  1. AFP, Alpha-fetoprotein; ALP, Alkaline phosphate; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; CRP, C-reactive protein; GFR, Estimated glomerular filtration rate; GGT, Gamma-glutamyl transferase; INR, International normalized ratio; PIVKA-II, Protein induced by vitamin K antagonist-II.