Association of BDNF and BMPR1A with clinicopathologic parameters in benign and malignant gallbladder lesions

Table 4 Multivariate Cox regression analysis of disease-specific survival in 65 patients who underwent surgical resection of gallbladder carcinoma

Group	Category	B	SE (B)	Exp (B)	P	95% CI for Exp (B)
Group	Category	B	SE (B)	Exp (B)	P	Inferior	Superior
Pathology type	Well/moderately/poorly differentiated carcinoma/mucous carcinoma	0.621	0.359	1.861	0.084	0.92	3.76
Tumor diameter	<20/20 mm	1.127	0.411	3.086	0.006	1.38	6.91
Lymph-node metastasis	No/yes	1.421	0.482	4.141	0.003	1.61	10.65
Invasion to surrounding tissue	No/yes	1.120	0.385	3.065	0.004	1.44	6.52
Surgery	Radical/ palliative	1.340	0.457	3.819	0.003	1.66	9.35
BDNF	Positive/negative	1.406	0.439	4.080	0.001	1.73	9.65
BMPR1A	Negative/positive	−0.885	0.389	0.413	0.023	0.19	0.89

Abbreviations: BDNF, brain-derived neurotrophic factor; BMPR1A bone morphogenetic protein receptor type IA; Exp, exponential; SE, standard error. B in SPSS means regression coefficient. SE (B) means Standard error B. Exp(B) in SPSS means Hazard ratio, also called relative risk.

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