Association of BDNF and BMPR1A with clinicopathologic parameters in benign and malignant gallbladder lesions

Table 3 Relationships between brain-derived neurotrophic factor (BDNF) and bone morphogenetic protein receptor type IA (BMPR1A) expression and clinicopathologic characteristics and average survival of patients with gallbladder adenocarcinoma

Clinicopathologic characteristics	Cases, n	Average survival, months	P
Gender
Male	18	10.0 (4 to 16)	0.910
Female	47	10.0 (4 to 18)
Age, years
≤ 45	11	8.0 (4 to 14)	0.121
> 45	54	10.0 (4 to 18)
Pathological type
Well differentiated	27	11.2 (4 to 18)	0.03
Moderately differentiated	20	10.0 (4 to 18)
Poorly differentiated	12	8.0 (4 to 10)
Mucinous adenocarcinoma	6	10.0 (6 to 16)
Maximum, diameter of mass, mm
< 20	19	14.0 (4 to 18)	0.003
≥ 20	46	8.0 (4 to 18)
Metastasis to lymph node
No	35	12.0 (4 to 18)	0.005
Yes	30	8.0 (4 to 18)
Invasion to surrounding tissue
No	38	10.0 (4 to 18)	0.002
Yes	27	8.0 (4 to 16)
T stage
T1	14	12.6 (6 to 18)	0.031
T2	23	10.7 (4 to 18)
T3	19	8.0 (4 to 18)
T4	9	6.2 (4 to 10)
Gallstones
No	29	10.9 (4 to 18)	0.135
Yes	36	9.8 (4 to 18)
BDNF
Positive	32	9.1 (4 to 18)	0.013
Negative	33	11.9 (6 to 18)
BMPR1A
Positive	31	11.7 (6 to 18)	0.042
Negative	34	9.5 (4 to 18)

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