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Table 2 Expression of brain-derived neurotrophic factor (BDNF) and bone morphogenetic protein receptor type IA (BMPR1A) and their correlation with the clinicopathologic parameters of gallbladder adenocarcinoma

From: Association of BDNF and BMPR1A with clinicopathologic parameters in benign and malignant gallbladder lesions

Clinicopathologic features

Cases

BDNF

BMPR1A

Positive cases, n (%)

χ 2

P

Positive cases, n (%)

χ 2

P

Gender

 Male

30

13 (43.3)

2.36

>0.05

14 (46.7)

0.69

>0.05

 Female

70

42 (60.0)

39 (55.7)

Age, years

  ≤ 45

22

10 (45.5)

1.04

>0.05

10 (45.5)

0.65

>0.05

  > 45

78

45 (57.7)

43 (55.1)

Pathological typea,b,c

 Well differentiated

36

13 (36.1)

11.60

<0.05

26 (72.2)

12.40

<0.05

 Moderately differentiated

29

16 (55.2)

14 (48.3)

 Poorly differentiated

25

20 (80.0)

8 (32.0)

 Mucinous adenocarcinoma

10

6 (60.0)

5 (50.0)

Maximum diameter of mass, mm

  < 20

29

11 (37.9)

4.81

<0.05

20 (69.0)

4.18

<0.05

  ≥ 20

71

44 (62.0)

33 (46.5)

Metastasis to lymph node

 No

47

19 (40.4)

7.61

<0.01

31 (66.0)

5.98

<0.05

 Yes

53

36 (67.9)

22 (41.5)

Invasion to surrounding tissue

 No

46

20 (43.5)

4.57

<0.05

30 (65.2)

5.10

<0.05

 Yes

54

35 (64.8)

23 (42.6)

T stage

 T1

22

8 (36.4)

8.28

<0.05

16 (72.7)

11.79

<0.05

 T2

35

16 (45.7)

20 (57.1)

 T3

29

21 (72.4)

12 (41.4)

 T4

14

10 (71.4)

5 (35.7)

Gallstones

 No

47

23 (48.9)

1.32

>0.05

22 (46.8)

1.37

>0.05

 Yes

53

32 (60.4)

31 (58.5)

  1. aWell-differentiated compared with moderately differentiated for BDNF: χ = 2.36, P > 0.05; and for BMPR1A: χ2 = 1.56, P > 0.05.
  2. bWell-differentiated compared with poorly differentiated for BDNF: χ2 = 11.44, P < 0.01; and for BMPR1A: χ2 = 9.68, P < 0.01.
  3. cModerately differentiated compared with poorly differentiated for BDNF: χ2 = 3.72, P = 0.05; and for BMPR1A: χ2 = 1.47, P > 0.05.