Depth of colorectal-wall invasion and lymph-node involvement as major outcome factors influencing surgical strategy in patients with advanced and recurrent ovarian cancer with diffuse peritoneal metastases

Table 4 Prognostic factors and five-year survival by univariate and multivariate analysis (52 patients)

Prognostic factors	Variables	Five-year survival	P* (univariate analysis)	P** (multivariate analysis)
Patients’ age (years)	<62	52.2%	0.49	0.79
Patients’ age (years)	≥62	41.2%	0.49	0.79
Ascites	Absent	39.2%	0.97	0.08
Ascites	Present	47.5%	0.97	0.08
Obstruction	Absent	56.7%	0.64	0.59
Obstruction	Present	25.4%	0.64	0.59
Cytoreduction	Primary	47.2%	0.98	0.73
Cytoreduction	Secondary	37.4%	0.98	0.73
Peritoneal cancer index	<18	53.5%	0.08	0.17
Peritoneal cancer index	≥18	33.6%	0.08	0.17
Completeness of cytoreduction score	CC-0	55%	0.002	0.003
Completeness of cytoreduction score	CC 1-3	25.7%	0.002	0.003
Depth of colorectal wall involvement	Serosal layer	72.7%	0.037	0.004
	Muscular layer	33.1%
	Mucosa layer	0%
Lymph node status	N0	41.3%	0.67	0.76
	N+ (A)	75%
	N+ (B)	42.5%
	N+ (A + B)	27.7%

P* by log-rank test; P** by Cox regression model. A, locoregional lymph nodes; B, mesenteric lymph nodes.

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