Table 1 Results of all published reports of extranodal soft tissue Rosai Dorfman disease (1988 to 2012)

1

Suster et al, 1988 [7]

Lateral upper right arm and middle third of left thigh

72

F

Multiple firm flesh-colored subcutaneous nodules

S-100+

No

7 years; spontaneous resolution

2

Rasool et al, 1996 [8]

Right index finger

10 mo

F

Right index finger swelling, pain, axilla, axillary lymph node

NR

Yes

14 months, no recurrence

3

Govender et al, 1997 [9]

Chest wall

34

F

Superficial firm mass

S-100+

Yes

6 months, no recurrence

CD68+

4

Child et al, 1998 [10]

Posterior left thigh

36

F

Hyperpigmented indurated plaque with multiple nodules, occasional pain

S-100+

No

12 months; no new lesions, new nodules within plaque

CD68+

5

Quaglino et al, 1998 [11]

Skin of arms and buttocks

70

F

Nodules on arms, face, buttock

S-100+

NR

NR

CD1a–

6

Huang et al, 2001 [12]

Medial right upper arm

43

F

Numbness and paresthesias of forearm and wrist

S-100+

Yes

12 months; no recurrence, mild hypoesthesia over lesion site

CD68+

7

Stefanato et al, 2002 [13]

Upper back, thighs, feet

55

F

Firm reddish brown dome-shaped papules with a single episode of belpharoconjunctivitis

S-100+

No

24 months; spontaneous resolution

CD1a–

8

Yoon et al, 2005 [5]

Left ankle, right forearm and arm

36

M

Nontender mobile nodules, left ankle pain, epistaxis

S-100+

Yes

4 months; recurrence in right maxillary sinus

9

Kong et al, 2007 [1]

Upper right arm

55

M

Flat-topped papules and nodules

S-100+

No

55 months; spontaneous resolution

CD68+

10

Kong et al, 2007 [1]

Left thigh and back

65

M

Brown plaque and nodules

S-100+

No

31 months; partial regression

CD68+

11

Kong et al, 2007 [1]

Left thigh

49

F

Red to brown nodules, tenderness

S-100+

No

31 months; partial regression

CD68+

12

Kong et al, 2007 [1]

Left chest

51

M

Pinkish papules

S-100+

Yes

28 months; no recurrence at original site but appearance of papules in popliteal area

CD68+

13

Kong et al, 2007 [1]

Left upper back

52

M

Red to dark-red papules, pruritis

S-100+

No

27 months; spontaneous resolution

CD68+

14

Kong et al, 2007 [1]

Lower back

45

M

Clusters of pinkish papules

S-100+

Yes

26 months; no recurrence

CD68+

15

Kong et al, 2007 [1]

Upper left arm

52

F

Red to brownish plaque with scattered papules and nodules

S-100+

Yes

8 months, no recurrence

CD68+

CD1a+

16

Kong et al, 2007 [1]

Right thigh and left calf

55

M

Hyperpigmented infiltrated plaque with papules surrounding

S-100+

No

24 months; persistence

CD68+

17

Kong et al, 2007 [1]

Left arm and right thigh

70

F

Erythematous papuloplaques with papulovesicles and pustules, pruritis

S-100+

No

24 months; partial regression

CD68+

18

Kong et al, 2007 [1]

Left arm and sacral back

48

M

Pinkish to red papules

S-100+

No

NR

CD68+

19

Kong et al, 2007 [1]

Left thigh

49

F

Brownish indurated plaque with satellite papules

S-100+

No

24 months; persistence

CD68+

20

Kong et al, 2007 [1]

Left thigh and back

43

M

Confluent papules and erythematous plaque

S-100+

Yes

7 months; no recurrence

CD68+

21

Kong et al, 2007 [1]

Right thigh

45

M

Plane hyperpigmented plaque

S-100+

Yes

15 months; no recurrence

CD68+

22

Kong et al, 2007 [1]

Suprasternal fossa and sacral back

56

F

Two dome-shaped, exophytic masses surrounded by few small papules, ulceration formed in one lesion

S-100+

Yes

15 months; no recurrence

CD68+

23

Kong et al, 2007 [1]

Right upper back

47

M

Single dark-red nodule

S-100+

Yes

14 months; no recurrence

CD68+

24

Kong et al, 2007 [1]

Abdomen and right buttock

21

M

Confluent papules and infiltrated plaque dotted with brownish papules

S-100+

No

12 months; slowly growing

CD68+

25

Kong et al, 2007 [1]

Upper right arm

42

M

Grouped pinkish papules, pain of wrist and shoulder

S-100+

No

11 months; persistence

CD68+

26

Kong et al, 2007 [1]

Face, buttock, abdomen and bilateral lower extremities

22

F

Multiple coalescing nodules, erythematous patches and plaques, some with tumorous appearance, pruritis

S-100+

No

NR

CD68+

27

Kong et al, 2007 [1]

Cheek, back and buttock

54

M

Dark-red and brownish nodules

S-100+

No

NR

CD68+

28

Kong et al, 2007 [1]

Upper left arm

52

F

Single subcutaneous mass, fever

S-100+

Yes

9 months, no recurrence

CD68+

29

Kong et al, 2007 [1]

Right cheek

40

M

Erythematous papuloplaque

S-100+

No

6 months; partial regression

CD68+

30

Kong et al, 2007 [1]

Right cheek

52

F

Erythematous papuloplaque

S-100+

No

5 months; persistence

CD68+

31

Kong et al, 2007 [1]

Left cheek and neck

38

M

Erythematous papuloplaque

S-100+

No

2 months; persistence

CD68+

32

Penna Costa et al, 2009 [3]

Left paravertebral mass in posterior mediastinum

49

F

Dyspnea and cough and cervical lymphadenopathy

S-100+

Yes

12 months; no recurrence

CD68+

CD1a–

33

Potts et al, 2008 [2]

Right forearm

31

F

Firm, hyperpigmented mass

NR

Yes

8 months; recurrence

7 months after re-excision; no recurrence

34

Molina-Garrido et al, 2011 [14]

Parieto-occipital cutaneous lesion

43

M

Red–yellow nodule, pain in right inferior maxillary area

S-100+

Yes

3 months; no recurrence

CD68+

CD1a–

CD20–

35

Shi et al, 2011 [15]

Face, neck extremities

45

F

Nonpruiginous papulonodular plaques

S-100+

No

5 weeks; partial regression

CD68+/–

CD1a–

36

Current study

Medial right thigh; Medial left thigh

56

F

Enlarging mass, knee joint pain

S-100+

Yes

9 months; no recurrence on right but new lesion on left

CD68+