Table 3 Meta-analysis of the association between the XRCC1 Arg194Trp and Arg399Gln genetic polymorphisms and the risk of bladder cancer
From: Quantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer risk
| Polymorphism | Stratification factor | Sample size | Number of studies | Test of association | Test of heterogeneity | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | P-value | z | Model | I2(%) | P-value | |||
| Arg194Trp | Overall | 4,751 | 6,102 | 14 | 1.69 (1.25-2.28) | 0.001 | 3.39 | F | 35.9 | 0.112 |
| Study in HWE | 4,301 | 5,659 | 12 | 2.07 (1.36-3.15) | 0.001 | 3.38 | F | 0.0 | 0.575 | |
| Ethnicity | ||||||||||
| Asian | 1,051 | 1,101 | 5 | 1.97 (1.04-3.74) | 0.038 | 2.08 | R | 64.1 | 0.025 | |
| Caucasian | 3,700 | 5,001 | 9 | 1.44 (0.75-2.74) | 0.270 | 1.10 | F | 0.0 | 0.538 | |
| Study quality | ||||||||||
| High | 3,956 | 5,111 | 8 | 2.08 (1.36-3.18) | 0.001 | 3.36 | F | 0 | 0.458 | |
| Low | 795 | 991 | 6 | 1.35 (0.88-2.08) | 0.352 | 0.93 | R | 71.6 | 0.030 | |
| Arg399Gln | Overall | 5,654 | 7,136 | 18 | 1.10 (1.03-1.19) | 0.008 | 2.67 | F | 0.0 | 0.596 |
| Study in HWE | 4,632 | 5,641 | 16 | 1.08 (1.00-1.18) | 0.053 | 1.94 | F | 0.0 | 0.858 | |
| Ethnicity | ||||||||||
| Asian | 1,364 | 1,438 | 6 | 1.14 (0.98-1.33) | 0.082 | 1.74 | F | 0.0 | 0.562 | |
| Caucasian | 4,290 | 5,698 | 12 | 1.09 (1.01-1.19) | 0.037 | 2.09 | F | 0.0 | 0.460 | |
| Study quality | ||||||||||
| High | 4,407 | 5,675 | 10 | 1.10 (1.01-1.19) | 0.028 | 2.20 | F | 0.0 | 0.819 | |
| Low | 1,247 | 1,461 | 8 | 1.13 (0.97-1.33) | 0.122 | 1.55 | R | 28.1 | 0.204 | |