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Table 3 Meta-analysis of the association between the XRCC1 Arg194Trp and Arg399Gln genetic polymorphisms and the risk of bladder cancer

From: Quantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer risk

Polymorphism Stratification factor Sample size Number of studies Test of association    Test of heterogeneity
Case Control OR (95% CI) P-value z Model I2(%) P-value
Arg194Trp Overall 4,751 6,102 14 1.69 (1.25-2.28) 0.001 3.39 F 35.9 0.112
  Study in HWE 4,301 5,659 12 2.07 (1.36-3.15) 0.001 3.38 F 0.0 0.575
  Ethnicity          
  Asian 1,051 1,101 5 1.97 (1.04-3.74) 0.038 2.08 R 64.1 0.025
  Caucasian 3,700 5,001 9 1.44 (0.75-2.74) 0.270 1.10 F 0.0 0.538
  Study quality          
  High 3,956 5,111 8 2.08 (1.36-3.18) 0.001 3.36 F 0 0.458
  Low 795 991 6 1.35 (0.88-2.08) 0.352 0.93 R 71.6 0.030
Arg399Gln Overall 5,654 7,136 18 1.10 (1.03-1.19) 0.008 2.67 F 0.0 0.596
  Study in HWE 4,632 5,641 16 1.08 (1.00-1.18) 0.053 1.94 F 0.0 0.858
  Ethnicity          
  Asian 1,364 1,438 6 1.14 (0.98-1.33) 0.082 1.74 F 0.0 0.562
  Caucasian 4,290 5,698 12 1.09 (1.01-1.19) 0.037 2.09 F 0.0 0.460
  Study quality          
  High 4,407 5,675 10 1.10 (1.01-1.19) 0.028 2.20 F 0.0 0.819
  Low 1,247 1,461 8 1.13 (0.97-1.33) 0.122 1.55 R 28.1 0.204
  1. CI, confidence interval; F, fixed-effect model; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; R, random-effect model.