Table 3 Univariate analysis of risk factors related to tumor recurrence in patients with large HCC after hepatic resection

Gender - Female

1.076

0.531 to 2.182

0.838

Age

0.999

0.980 to1.019

0.933

AFP ≥ 1000

1.935

1.179 to 3.176

0.009

PIVKA-II ≥ 200

1.136

0.677 to 1.906

0.630

White blood cells

0.933

0.813 to 1.071

0.325

Hemoglobin

0.884

0.782 to 1.001

0.051

Platelet count

1.002

1.000 to 1.004

0.075

INR

2.822

0.154 to 51.533

0.484

Albumin

0.443

0.231 to 0.850

0.014

Total bilirubin

1.162

0.570 to 2.367

0.680

AST

1.002

0.998 to 1.006

0.313

ALT

1.000

0.996 to 1.004

0.919

ALP > 80 IU/mL

2.216

1.282 to 3.830

0.004

Glucose

0.998

0.993 to 1.004

0.998

Creatinine

0.787

0.368 to 1.683

0.537

Type of operation (non-anatomical)

1.402

0.711 to 2.768

0.330

Maximum tumor size

0.990

0.990 to 1.008

0.780

Cirrhosis

1.690

0.926 to 3.084

0.087

Grade (3 and 4)

1.141

0.612 to 2.130

0.678

Capsular invasion

0.532

0.277 to 1.020

0.057

Microvascular invasion

1.812

0.566 to 5.797

0.317

Portal vein invasion

1.642

0.933 to 2.889

0.085

Bile duct invasion

1.184

0.371 to 3.785

0.775

Serosa involvement

1.142

0.457 to 2.851

0.776

Intrahepatic metastasis

2.019

1.265 to 3.517

0.004

Multicentric occurrence

0.481

0.118 to 1.966

0.308