Figure 4

Immunohistochemical analysis of Case 2. (A) At low power, dilated pancreatic duct with normal epithelium is seen. At the lower left corner a pancreatic lesion with a few atypical secondary ducts is observed (arrow head); (B) At medium power, a few atypical ducts with a desmoplastic-like surrounding stroma is seen; (C) At high power, ducts are lined by irregular epithelium, with micronucleoli and irregular chromatin cells nuclei, suggestive but not consistent with carcinoma; (D) Ki-67 labeling shows nuclear reaction in less than 1% of the cells.