Table 3 Multivariate analysis of 5-year disease-free survival and melanoma-specific survival

Method of diagnosis

0.6

0.01

Sentinel lymph node biopsy

1

1

Clinical

1.1 (0.7 to 1.7)

1.7 (1.0 to 3.0)

Primary site^a

0.05

0.07

Trunk

1

1

Lower extremity

0.5 (0.3 to 0.9)

0.6 (0.3 to 1.1)

Unknown

1.1 (0.3 to 3.6)

21.7 (0.5 to 5.6)

T stage

0.05

0.09

T1 to T2

1

1

T3

2.2 (1.2 to 4.1)

2.5 (1.1 to 5.6)

T4

1.6 (0.8 to 3.0)

1.6 (0.6 to 3.8)

Ulceration^b

0.3

0.06

No

1

1

Yes

1.3 (0.7 to 2.3)

1.9 (1.0 to 3.7)

Number of positive lymph nodes

0.006

0.003

1 (N1)

1

1

2 or 3 (N2)

1.2 (0.6 to 2.2)

1.6 (0.7 to 3.5)

≥4 (N3)

3.6 (1.6 to 7.8)

4.7 (1.9 to 11.5)

Extent of nodal involvement

0.001

0.002

Superficial

1

1

Superficial + deep

2.6 (1.4 to 4.6)

2.8 (1.5 to 5.5)