|
Clinical and pathological factors
|
Disease-free survival
|
P value
|
Melanoma-specific survival
|
P value
|
|---|
|
Method of diagnosis
| |
0.6
| |
0.01
|
|
Sentinel lymph node biopsy
|
1
| |
1
| |
|
Clinical
|
1.1 (0.7 to 1.7)
| |
1.7 (1.0 to 3.0)
| |
|
Primary sitea
| |
0.05
| |
0.07
|
|
Trunk
|
1
| |
1
| |
|
Lower extremity
|
0.5 (0.3 to 0.9)
| |
0.6 (0.3 to 1.1)
| |
|
Unknown
|
1.1 (0.3 to 3.6)
| |
21.7 (0.5 to 5.6)
| |
|
T stage
| |
0.05
| |
0.09
|
|
T1 to T2
|
1
| |
1
| |
|
T3
|
2.2 (1.2 to 4.1)
| |
2.5 (1.1 to 5.6)
| |
|
T4
|
1.6 (0.8 to 3.0)
| |
1.6 (0.6 to 3.8)
| |
|
Ulcerationb
| |
0.3
| |
0.06
|
|
No
|
1
| |
1
| |
|
Yes
|
1.3 (0.7 to 2.3)
| |
1.9 (1.0 to 3.7)
| |
|
Number of positive lymph nodes
| |
0.006
| |
0.003
|
|
1 (N1)
|
1
| |
1
| |
|
2 or 3 (N2)
|
1.2 (0.6 to 2.2)
| |
1.6 (0.7 to 3.5)
| |
|
≥4 (N3)
|
3.6 (1.6 to 7.8)
| |
4.7 (1.9 to 11.5)
| |
|
Extent of nodal involvement
| |
0.001
| |
0.002
|
|
Superficial
|
1
| |
1
| |
|
Superficial + deep
|
2.6 (1.4 to 4.6)
| |
2.8 (1.5 to 5.5)
| |
