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Table 3 Multivariate analysis of 5-year disease-free survival and melanoma-specific survival

From: Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors

Clinical and pathological factors Disease-free survival P value Melanoma-specific survival P value
Method of diagnosis   0.6   0.01
Sentinel lymph node biopsy 1   1  
Clinical 1.1 (0.7 to 1.7)   1.7 (1.0 to 3.0)  
Primary sitea   0.05   0.07
Trunk 1   1  
Lower extremity 0.5 (0.3 to 0.9)   0.6 (0.3 to 1.1)  
Unknown 1.1 (0.3 to 3.6)   21.7 (0.5 to 5.6)  
T stage   0.05   0.09
T1 to T2 1   1  
T3 2.2 (1.2 to 4.1)   2.5 (1.1 to 5.6)  
T4 1.6 (0.8 to 3.0)   1.6 (0.6 to 3.8)  
Ulcerationb   0.3   0.06
No 1   1  
Yes 1.3 (0.7 to 2.3)   1.9 (1.0 to 3.7)  
Number of positive lymph nodes   0.006   0.003
1 (N1) 1   1  
2 or 3 (N2) 1.2 (0.6 to 2.2)   1.6 (0.7 to 3.5)  
≥4 (N3) 3.6 (1.6 to 7.8)   4.7 (1.9 to 11.5)  
Extent of nodal involvement   0.001   0.002
Superficial 1   1  
Superficial + deep 2.6 (1.4 to 4.6)   2.8 (1.5 to 5.5)