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Table 3 Histopathological data comparing patients who underwent radical resections following NACT (n = 126) from group 1 with patients who underwent upfront surgery (n = 62) from group 2

From: D2 lymphadenectomy is not only safe but necessary in the era of neoadjuvant chemotherapy

  Resected patients from group 1 (n = 126) Resected patients from group 2 (n = 62)
Final pathology   
Carcinoma in situ - 1 (2%)
Well-differentiated adenocarcinoma 4 (3%) 5 (8%)
Moderately-differentiated adenocarcinoma 27 (21%) 17 (27%)
Poorly differentiated adenocarcinoma 57 (45%) 33 (53%)
Signet ring cell adenocarcinoma 16 (13%) 6 (10%)
Microscopic foci of adenocarcinoma 7 (6%) -
No residual tumor 15 (12%) -
T-stage   
T1 9 10
T2 26 14
T3 54 18
T4 20 20
Perineural invasion present 22 (17%) 9 (14.5%)
Lymphovascular invasion present 45 (36%) 36 (58%)
Median number of lymph nodes harvested (range) 16 (1 to 53) 18 (3 to 39)
Median number of positive nodes (range) 1 (0 to 22) 2 (0 to 22)
Lymph node ratio (range) 0.07 (0 to 1.0) 0.14 (0 to 0.95)