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Table 2 Univariate analysis of relapse-free survival and overall survival

From: Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy

Factor Relapse-free survival Overall survival Factor Relapse-free survival Overall survival
  P Hazard ratio (95% confidence interval) P Hazard ratio (95% confidence interval)   P Hazard ratio (95% confidence interval) P Hazard ratio (95% confidence interval)
Age          
<45y vs. ≥45y 0.724 1.2 (0.5 to 2.7) 0.256 1.0 (0.9 to 1.0)      
Menopausal status          
Premenopausal vs. Postmenopausal 0.663 0.9 (0.5 to 1.5) 0.822 1.0 (0.6 to 2.0)      
Regimen          
CEF vs. NE 0.479 1.2 (0.7 to 2.0) 0.568 1.2 (0.6 to 2.2)      
Tumor size          
≤5 cm vs. >5 cm 0.784 1.1 (0.6 to 2.0) 0.456 1.3 (0.6 to 2.8)      
Lymph node status          
Negative          
1 to 3 nodes + 0.007 2.7 (1.3 to 5.6) 0.012 4.3 (1.4 to 13.3)      
4 to 9 nodes + <0.001 4.6 (2.2 to 9.5) 0.001 7.2 (2.4 to 21.9)      
≥10 nodes + <0.001 6.8 (3.0 to 15.9) <0.001 13.7 (4.3 to 44.4)      
Pre-estrogen receptor      Post-estrogen receptor     
Negative vs. positive 0.252 1.4 (0.8 to 2.3) 0.620 1.2 (0.6 to 2.2) Negative vs. positive 1.000 1.0 (0.5 to 1.8) 0.540 0.8 (0.4 to 1.7)
Pre-progesterone receptor      Post-progesterone receptor     
Negative vs. positive 0.724 0.9 (0.5 to 1.6) 0.334 0.7 (0.3 to 1.5) Negative vs. positive 0.841 1.0 (0.6 to 2.0) 0.754 0.9 (0.4 to 2.0)
Pre-Ki67      Post-Ki67     
Negative vs. positive 0.840 1.1 (0.6 to 1.8) 0.647 0.9 (0.5 to 1.6) Negative vs. positive 0.260 1.4 (0.8 to 2.3) 0.434 1.3 (0.7 to 2.4)
Pre-pMAPK      Post-pMAPK     
Negative vs. positive 0.174 0.7 (0.4 to 1.2) 0.788 1.1 (0.6 to 2.2) Negative vs. positive 0.019 2.0 (1.1 to 3.5) <0.001 3.7 (1.9 to 7.0)
Pre-pAKT      Post-pAKT     
Negative vs. positive 0.224 0.7 (0.4 to 1.2) 0.104 0.6 (0.3 to 1.1) Negative vs. positive 0.551 0.8 (0.5 to 1.5) 0.548 0.8 (0.4 to 1.7)
Pre-PTEN      Post-PTEN     
Negative vs. positive 0.450 0.8 (0.5 to 1.4) 0.538 0.8 (0.4 to 1.5) Negative vs. positive 0.622 0.9 (0.5 to 1.6) 0.571 1.3 (0.6 to 2.7)
Pre-P27      Post-P27     
Negative vs. positive 0.929 1.0 (0.6 to 1.6) 0.439 0.8 (0.4 to 1.5) Negative vs. positive 0.220 1.4 (0.8 to 2.5) 0.317 1.4 (0.7 to 2.9)
Pre-IGF-1R      Post-IGF-1R     
Negative vs. positive 0.728 1.1 (0.7 to 1.8) 0.874 1.1 (0.6 to 2.0) Negative vs. positive 0.388 0.8 (0.5 to 1.3) 0.760 1.1 (0.6 to 2.2)
Pre-cyclinD1      Post-cyclinD1     
Negative vs. positive 0.606 1.2 (0.7 to 2.0) 0.814 1.1 (0.6 to 2.1) Negative vs. positive 0.602 1.2 (0.7 to 2.1) 0.912 1.0 (0.5 to 2.1)
  1. IGF-1R, insulin-like growth factor 1 receptor; pAKT, phosphorylated AKT; pMAPK, phosphorylated mitogen-activated protein kinase.