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Table 5 Summary of published studies reporting the expression of ALDH1 in carcinoma

From: Aldehyde dehydrogenase 1 expression in primary and metastatic renal cell carcinoma: an immunohistochemistry study

Number of patients Patient population (Publication year) Tissue and methods Expression compared to normal tissue Association with high histologic grade Association with high TNM staging Expression in metastasis compared to primary Prognostic factor
Breast cancer
106 Triple negative mammary carcinoma (2011) [31] FFPE, IHC N/A ↑ for epithelial cells - for stromal cells N/A N/A ↓for epithelial cells
606 Invasive mammary carcinoma, DCIS (2012) [24] TMA, IHC N/A - N/A N/A
140 2012-Triple negative mammary carcinoma [25] TMA, IHC N/A - - N/A ↑ for stromal cells
Gastrointestinal cancer
190 Gastric carcinoma (2012) [32] FFPE, IHC N/A -
96 Colorectal carcinoma (2012) [29] FFPE, IHC N/A -
1420 Colorectal carcinoma (2010) [33] TMA, IHC + N/A N/A -
186 Colorectal carcinoma (2012) [34] TMA, IHC N/A N/A N/A N/A ↓ (for cells that were positive for beta-catenin in the nucleus)
Gynecological cancer
442 Ovarian carcinoma (2009) [28] TMA, IHC N/A - N/A
84 Ovarian carcinoma (2012) [35] TMA, IHC N/A - - N/A
28 Serous ovarian carcinoma (2010) [36] TMA, IHC, RT-PCR, Western N/A N/A N/A N/A
98 Endometrioid ovarian carcinoma (2010) [37] IHC N/A - N/A
Hepatobiliary and pancreatic cancer
49 Hepatocellular carcinoma (2012) [38] FFPE, IHC N/A - N/A
100 Gallbladder adenocarcinoma (2010) [26] FFPE, IHC N/A N/A
97 Pancreatic adenocarcinoma (2011) [39] IHC, RT-PCR, Western N/A - - N/A
78 Pancreatic adenocarcinoma (2012) [40] TMA, IHC N/A N/A N/A N/A -
  1. N/A: data not available.
  2. ↑: Increased expression or positive correlation.
  3. -: No association.
  4. ↓: Decreased expression or negative correlation.
  5. FFPE: immunohistochemistry on formalin-fixed paraffin-embedded tissue; IHC: immunohistochemistry; RT-PCR: quantitative real time-polymerase chain reaction TMA: tissue microarray; Western: Western blot.