Table 2 Clinicopathological findings and follow-up for the 12 studied cases of inflammatory myofibroblastic tumor
From: Expression of hypoxia-related markers in inflammatory myofibroblastic tumors of the head and neck
Case | Sex | Age | Site | CT, MRI, PET | Treatment | Recurrence | Metastasis | Follow-up |
|---|---|---|---|---|---|---|---|---|
1 | M | 64 | Larynx | / | Laryngeal fissure, complete excision, clear margin | No | No | No evidence of disease(68 months) |
2 | M | 22 | Tonsil | / | Tonsillectomy, clear margin | No | No | No evidence of disease(84 months) |
3 | M | 33 | Maxillare | CT showed a softtissue mass in the right maxillary alveolar bone. The local bone of maxillary alveolar and inferior wall of right maxillary sinus, and the mass extended into the right maxillary sinus, mild to moderate enhancement on contrast-enhancement. | Local excision | Yes, 6 years after first surgery. Total maxillectomy was performed. | No | No evidence of disease(16 months after second surgery) |
4 | M | 48 | Tongue | CT showed a 3.7 × 1.7 cm irregular softtissue mass in the left base of tongue, strong enhancement on contrast-enhanced imaging. | Local complete excision, clear margin | No | No | No evidence of disease(41 months) |
5 | F | 61 | Tonsil | CT showed a 2.6 × 1.8 cm irregular soft tissue mass between the left tonsil and the base of the tongue with no enhancement on contrast-enhanced imaging. | Left tonsillectomy and mass excision, clear margin | No | No | No evidence of disease(23 months) |
6 | F | 46 | Hypopharynx | MRI showed that a 1.3 × 2.2 cm mass in the right pyriform sinus. Isointense and slight hypointense on T1-weighted imaging, hyperintense on T2 -weighted imaging, heterogeneous enhancement on contrast-enhanced T1-weighted MRI images. | Excision under suspension laryngoscopy | Yes, 37 months after initial surgery. Second surgery was performed via lateral neck incision. | No | No evidence of disease(10 months after second surgery) |
7 | F | 46 | Maxillary sinus | CT showed a diffuse softtissue massin the right maxillary sinus with destruction of the maxillary bone anteriorly and inwardly that extended into the orbit causing exophthalmos anteriorly. | Exploratory operation, oral corticosteroids | Yes, 2 months after initial treatment. Then the patient received total maxillectomy and exenteration + radiotherapy postoperation.1 month after second surgery, recurrence occurred. | Metastasis to cervical lymph node | Died of disease (13 months after initial treatment) |
8 | F | 25 | Mouth floor | / | Local excision, clear margin | No | No | No evidence of disease(132 months) |
9 | F | 63 | Maxillary sinus | A homogeneous mass in the left maxillary sinus on the CT scan. | Partial maxillectomy neck dissection, 50 Gy radiotherapy was performed. | 8 months after initial treatment, occurrence was occurred. Another 50 Gy radiotherapy was given. | Metastasis to cervical lymph node | Died of disease (11 months after first treatment) |
10 | F | 48 | Maxillary sinus | CT showed a softtissue expansile mass in the left maxillary sinus. | Partial maxillectomy + corticosteroids | Recurrence 6 months after initial treatment. Total maxillectomy + corticosteroids. | No | No evidence of disease(70 months after first treatment) |
11 | F | 34 | Maxillary sinus | CT showed a softtissue expansile mass in the left maxillary sinus extending to the nasal septum | Caldwell-Luc operation | Recurrence 1 month after first surgery. Partial maxillectomy + oral prednisone. Tumor was not contained.3 months later, 60Gy radiotherapy also did not contain the tumor. Endoscopic surgery and total maxillectomy did not control the tumor. | No | Died of disease (35 months after initial treatment) |
Follow-up showed PET/CT showed high FDG uptake in the left maxillary sinus. | ||||||||
12 | F | 43 | Neck | A 3 × 4 × 11 cm well-defined mass in the right neck, hyperintense on T1,hypointense on T2, heterogeneous enhancement on contrast-enhanced T1-weighted MRI images. MRI findings suggested neurogenic tumor. CT showed a well-defined, heterogeneous mass in the right neck, mild enhancementon contrast-enhanced imaging. | Complete excision, clear margin | No | No | No evidence of disease(13 months) |