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Table 3 Univariate and multivariate analysis of factors associated with survival

From: Prognostic value of isocitrate dehydrogenase 1, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients

  Univariate Cox regression Multivariate Cox regression
  HR 95% CI P-value HR 95% CI P-value
Group 1 (AA + GBM)       
Age (per year) 1.023 1.014–1.033 <0.0001 1.023 1.013–1.034 <0.0001
Gender (female versus male) 1.023 1.014–1.033 <0.0001 0.810 0.590–1.112 0.1928
Resection (total resection versus non-total resection) 1.348 0.987–1.840 0.06 1.994 1.440–2.763 <0.0001
IDH1 (mutation versus wild-type) 0.427 0.253–0.719 0.0014 0.708 0.403–1.243 0.2290
MGMT (methylation versus unmethylation) 0.671 0.494–0.911 0.0106 0.614 0.442–0.852 0.0035
Histology (AA versus GBM) 0.372 0.242–0.571 <0.0001 0.419 0.264–0.666 0.0002
Group 2 (AO + AOA)
Age (per year) 1.025 0.971–1.083 0.3672 1.094 1.003–1.193 0.0421
Gender (female versus male) 0.499 0.145–1.717 0.2703 0.156 0.027–0.890 0.0365
Resection (total resection versus non-total resection) 0.886 0.289–3.031 0.037 0.852 0.178–4.074 0.8412
IDH1 (mutation versus wild-type) 0.563 0.172–1.848 0.3436 2.271 0.415–12.444 0.3444
MGMT (methylation versus unmethylation) 0.115 0.033–0.402 0.0007 0.041 0.007–0.257 0.0006
1p19q (co-deletion versus non co-deletion) 4.208 1.099–16.114 0.0359 4.720 0.685–32.526 0.1150
Histology (AO versus AOA) 0.723 0.220–2.377 0.5937 1.935 0.383–9.785 0.4247
  1. AO, anaplastic oligodendroglioma; AOA, anaplastic oligoastrocytoma; AA, anaplastic astrocytoma; GBM, glioblastoma; HR, hazard ratio.