Table 2 Clinical and genetic features of patients with malignant glioma with and without isocitrate dehydrogenase 1 (IDH1) mutation
| Â | Â | IDH1 | Â | |
|---|---|---|---|---|
| Â | Â | Mutation (+) | Mutation (-) | P-value |
AO | Cases , number | 20 | 10 | Â |
| Â | Gender | Â | Â | Â |
| Â | Male, number | 8 | 5 | NS |
| Â | Female, number | 12 | 5 | Â |
| Â | Age, mean, years | 48.3 | 44.4 | NS |
| Â | Karnofsky performance status, mean score, % | 94.5 | 89 | NS |
| Â | Surgery | Â | Â | Â |
| Â | Total, number | 16 | 6 | NS |
| Â | Partial or biopsy, number | 4 | 4 | Â |
| Â | MGMT promoter | Â | Â | Â |
| Â | Methylation (+), number | 19 | 5 | 0.0155 |
| Â | Methylation (-), number | 1 | 5 | Â |
| Â | 1p 19 co-deletion, number | 11 | 7 | NS |
| Â | Survival, median, months | 72 | 69 | NS |
AOA | Cases, number | 12 | 14 | Â |
| Â | Gender | Â | Â | Â |
| Â | Male, number | 5 | 10 | NS |
| Â | Female, number | 7 | 4 | Â |
| Â | Age, mean, years | 46.4 | 48.7 | NS |
| Â | Karnofsky performance status, mean score, % | 97.5 | 96.4 | NS |
| Â | Surgery | Â | Â | Â |
| Â | Total, number | 5 | 8 | NS |
| Â | MGMT promoter | Â | Â | Â |
| Â | Methylation (+), number | 11 | 8 | 0.0479 |
| Â | Methylation (-), number | 1 | 6 | Â |
| Â | 1p 19q co-deletion, number | 7 | 4 | NS |
| Â | Survival, median, months | 88 | 65 | NS |
AA | Cases, number | 12 | 28 | Â |
| Â | Gender | Â | Â | Â |
| Â | Male, number | 8 | 14 | NS |
| Â | Female, number | 4 | 14 | Â |
| Â | Age,mean, years | 41.7 | 44.3 | NS |
| Â | Karnofsky performance status, mean score, % | 90.8 | 78.9 | NS |
| Â | Surgery | Â | Â | Â |
| Â | Total, number | 4 | 4 | NS |
| Â | Partial or biopsy, number | 8 | 24 | Â |
| Â | MGMT promoter | Â | Â | Â |
| Â | Methylation (+), number | 9 | 9 | 0.0125 |
| Â | Methylation (-), number | 3 | 19 | Â |
| Â | Survival, median, months | 55 | 25 | 0.0786 |
GBM | Cases, number | 12 | 159 | Â |
| Â | Tumor occurrence | Â | Â | Â |
| Â | Primary, number | 4 | 155 | 0.0001 |
| Â | Secondary, number | 8 | 4 | Â |
| Â | Gender | Â | Â | Â |
| Â | Male, number | 6 | 99 | NS |
| Â | Female, number | 6 | 60 | Â |
| Â | Age, mean, years | 43.8 | 58.5 | 0.004 |
| Â | Karnofsky performance status, mean score, % | 87.5 | 79.7 | NS |
| Â | Surgery | Â | Â | Â |
| Â | Total, number | 3 | 71 | NS |
| Â | Partial or biopsy, number | 9 | 88 | Â |
| Â | MGMT promoter | Â | Â | Â |
| Â | Methylation (+), number | 10 | 63 | 0.0032 |
| Â | Methylation (-), number | 2 | 96 | Â |
| Â | Survival, median, months | 20 | 14 | 0.0051 |