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Table 2 Univariate analysis of disease-free survival (DFS) and overall survival (OS) of esophageal squamous cell carcinoma (ESCC) patients

From: Expression of epidermal growth factor receptor is an independent prognostic factor for esophageal squamous cell carcinoma

 

N

Disease-free survival

Overall survival

HR

95% CI

P value

HR

95% CI

P value

Gender

       

  Male (ref)

176

1

  

1

  

  Female

67

1.202

0.894 to 1.616

0.222

1.223

0.906 to 1.650

0.188

Age (y)

0.154

  

0.178

  <40 (ref)

12

1

  

1

  

  41 to50

56

0.531

0.265 to 1.066

0.075

0.559

0.278 to 1.121

0.101

  51 to 60

101

0.720

0.500 to 1.037

0.078

0.716

0.496 to 1.035

0.075

  60 to 68

74

0.857

0.631 to 1.164

0.324

0.875

0.643 to 1.190

0.395

Length (cm)

0.008

  

0.011

  ≤5.0 (ref)

130

1

  

1

  

  5.1 to 7.0

90

0.546

0.345 to 0.864

0.100

0.563

0.356 to 0.890

0.014

  >7.0

23

0.762

0.477 to 1.218

0.256

0.781

0.488 to 1.248

0.301

Tumor location

0.104

  

0.204

  Upper (ref)

33

1

  

1

  

  Middle

155

1.611

1.029 to 2.520

0.037

1.502

0.961 to 2.349

0.075

  Lower

55

1.280

0.925 to 1.772

0.136

1.166

0.842 to 1.615

0.354

Histological differentiation

   

0.012

  

0.325

  Well

93

1

  

1

  

  Moderate

124

1.418

1.064 to 1.891

0.017

1.296

0.972 to 1.727

0.077

  Poor

26

1.271

1.059 to 1.526

0.010

1.247

1.039 to 1.497

0.018

EGFR expression

       

  Low (ref)

56

1

  

1

  

  High

187

1.974

1.413 to 2.758

<0.0001

2.075

1.485 to 2.899

<0.0001

Tumor stage

   

<0.0001

  

<0.0001

  T2 (ref)

31

1

  

1

  

  T3

168

1.303

0.874 to 1.940

0.192

1.320

0.886 to 1.967

0.170

  T4

44

1.468

1.146 to 1.880

0.002

1.532

1.194 to 1.965

0.002

N stagea

       

  N0 (ref)

130

1

  

1

  

  N1

113

2.203

1.676 to 2.897

<0.001

2.267

1.723 to 2.983

<0.001

Stagea

   

<0.0001

  

<0.0001

  IIA (ref)

110

1

  

1

  

  IIB

8

1.343

0.650 to 2.776

0.640

1.253

0.607 to 2.585

0.541

  III

125

1.539

1.336 to 1.771

<0.0001

1.583

1.373 to 1.824

<0.0001

N stageb

   

<0.0001

  

<0.0001

  N0 (ref)

130

1

  

1

  

  N1

65

1.833

1.339 to 2.509

<0.0001

1.882

1.374 to 2.578

<0.0001

  N2

39

1.682

1.384 to 2.044

<0.0001

1.756

1.442 to 2.138

<0.0001

  N3

9

1.701

1.338 to 2.161

<0.0001

1.532

1.210 to 1.940

<0.0001

Stageb

   

<0.0001

  

<0.0001

  IB (ref)

23

1

  

1

  

  IIA

87

0.969

0.596 to 1.576

0.899

0.939

0.577 to 1.529

0.801

  IIB

5

0.971

0.590 to 1.599

0.908

0.908

0.555 to 1.486

0.702

  IIIA

68

1.283

1.082 to 1.523

0.003

1.289

1.086 to 1.529

0.003

  IIIB

28

1.386

1.168 to 1.644

<0.0001

1.433

1.203 to 1.708

<0.0001

  IIIC

32

1.280

1.123 to 1.458

<0.0001

1.306

1.145 to 1.489

0.967

  1. HR, hazard ratio; CI, confidence interval; P value was calculated by using a log-rank test; ref, reference.
  2. aUICC, sixth edition.
  3. bUICC, seventh edition.