| N | Disease-free survival | Overall survival | ||||
---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | ||
Gender | Â | Â | Â | Â | Â | Â | Â |
  Male (ref) | 176 | 1 |  |  | 1 |  |  |
  Female | 67 | 1.202 | 0.894 to 1.616 | 0.222 | 1.223 | 0.906 to 1.650 | 0.188 |
Age (y) | 0.154 | Â | Â | 0.178 | |||
  <40 (ref) | 12 | 1 |  |  | 1 |  |  |
  41 to50 | 56 | 0.531 | 0.265 to 1.066 | 0.075 | 0.559 | 0.278 to 1.121 | 0.101 |
  51 to 60 | 101 | 0.720 | 0.500 to 1.037 | 0.078 | 0.716 | 0.496 to 1.035 | 0.075 |
  60 to 68 | 74 | 0.857 | 0.631 to 1.164 | 0.324 | 0.875 | 0.643 to 1.190 | 0.395 |
Length (cm) | 0.008 | Â | Â | 0.011 | |||
  ≤5.0 (ref) | 130 | 1 |  |  | 1 |  |  |
  5.1 to 7.0 | 90 | 0.546 | 0.345 to 0.864 | 0.100 | 0.563 | 0.356 to 0.890 | 0.014 |
  >7.0 | 23 | 0.762 | 0.477 to 1.218 | 0.256 | 0.781 | 0.488 to 1.248 | 0.301 |
Tumor location | 0.104 | Â | Â | 0.204 | |||
  Upper (ref) | 33 | 1 |  |  | 1 |  |  |
  Middle | 155 | 1.611 | 1.029 to 2.520 | 0.037 | 1.502 | 0.961 to 2.349 | 0.075 |
  Lower | 55 | 1.280 | 0.925 to 1.772 | 0.136 | 1.166 | 0.842 to 1.615 | 0.354 |
Histological differentiation | Â | Â | Â | 0.012 | Â | Â | 0.325 |
  Well | 93 | 1 |  |  | 1 |  |  |
  Moderate | 124 | 1.418 | 1.064 to 1.891 | 0.017 | 1.296 | 0.972 to 1.727 | 0.077 |
  Poor | 26 | 1.271 | 1.059 to 1.526 | 0.010 | 1.247 | 1.039 to 1.497 | 0.018 |
EGFR expression | Â | Â | Â | Â | Â | Â | Â |
  Low (ref) | 56 | 1 |  |  | 1 |  |  |
  High | 187 | 1.974 | 1.413 to 2.758 | <0.0001 | 2.075 | 1.485 to 2.899 | <0.0001 |
Tumor stage | Â | Â | Â | <0.0001 | Â | Â | <0.0001 |
  T2 (ref) | 31 | 1 |  |  | 1 |  |  |
  T3 | 168 | 1.303 | 0.874 to 1.940 | 0.192 | 1.320 | 0.886 to 1.967 | 0.170 |
  T4 | 44 | 1.468 | 1.146 to 1.880 | 0.002 | 1.532 | 1.194 to 1.965 | 0.002 |
N stagea | Â | Â | Â | Â | Â | Â | Â |
  N0 (ref) | 130 | 1 |  |  | 1 |  |  |
  N1 | 113 | 2.203 | 1.676 to 2.897 | <0.001 | 2.267 | 1.723 to 2.983 | <0.001 |
Stagea | Â | Â | Â | <0.0001 | Â | Â | <0.0001 |
  IIA (ref) | 110 | 1 |  |  | 1 |  |  |
  IIB | 8 | 1.343 | 0.650 to 2.776 | 0.640 | 1.253 | 0.607 to 2.585 | 0.541 |
  III | 125 | 1.539 | 1.336 to 1.771 | <0.0001 | 1.583 | 1.373 to 1.824 | <0.0001 |
N stageb | Â | Â | Â | <0.0001 | Â | Â | <0.0001 |
  N0 (ref) | 130 | 1 |  |  | 1 |  |  |
  N1 | 65 | 1.833 | 1.339 to 2.509 | <0.0001 | 1.882 | 1.374 to 2.578 | <0.0001 |
  N2 | 39 | 1.682 | 1.384 to 2.044 | <0.0001 | 1.756 | 1.442 to 2.138 | <0.0001 |
  N3 | 9 | 1.701 | 1.338 to 2.161 | <0.0001 | 1.532 | 1.210 to 1.940 | <0.0001 |
Stageb | Â | Â | Â | <0.0001 | Â | Â | <0.0001 |
  IB (ref) | 23 | 1 |  |  | 1 |  |  |
  IIA | 87 | 0.969 | 0.596 to 1.576 | 0.899 | 0.939 | 0.577 to 1.529 | 0.801 |
  IIB | 5 | 0.971 | 0.590 to 1.599 | 0.908 | 0.908 | 0.555 to 1.486 | 0.702 |
  IIIA | 68 | 1.283 | 1.082 to 1.523 | 0.003 | 1.289 | 1.086 to 1.529 | 0.003 |
  IIIB | 28 | 1.386 | 1.168 to 1.644 | <0.0001 | 1.433 | 1.203 to 1.708 | <0.0001 |
  IIIC | 32 | 1.280 | 1.123 to 1.458 | <0.0001 | 1.306 | 1.145 to 1.489 | 0.967 |