Mixed adeno(neuro)endocrine carcinoma arising from the ectopic gastric mucosa of the upper thoracic esophagus

Table 2 Summary of the cases of mixed adeno(neuro)endocrine carcinoma published in the English-language literature after 2010 ( N = 47)^a

Affected organ	Cases	Mean age (yr)	Sex (M/F)	SYN (+/−/unknown)	CGA (+/−/unknown)	CD56 (+/−/unknown)
Colon[6, 7]	13	71	9/4	13/0/0	13/0/0	0/0/13
Pancreas[39–46]	13	69	11/2	11/0/2	12/0/1	0/0/13
Gallbladder[47–50]	8	63	1/7	8/0/0	7/0/1	2/0/6
Biliary tract[46, 51, 52]	6	71	3/3	6/0/0	5/1/0	1/0/3
Stomach[53–56]	4	71	1/3	4/0/0	3/1/0	2/1/1
Ampulla[57]	1	81	1/0	1/0/0	1/0/0	0/0/1
Cecum[58]	1	68	0/1	1/0/0	1/0/0	0/0/1
Esophagogastric junction[59]	1	68	1/0	1/0/0	0/0/1	0/0/1

^aThe cases included in this table are those available in PubMed as of 5 August 2013. We grouped the cases that are expressed as mixed exocrine-endocrine carcinoma, mixed ductal-endocrine carcinoma and mixed acinar-endocrine carcinoma into a single mixed adenoneuroendocrine carcinoma (MANEC) category if they met the World Health Organization classification of endocrine tumors and the paper was published after 2010. We excluded the collision type of MANEC. CGA chromogranin A, SYN synaptophysin.

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