Figure 2

Correlation between vascular endothelial growth factor C (VEGF-C) and high-mobility group box 1 (HMGB1). A correlation coefficient revealed that VEGF-C expression was highly correlated with HMGB1 in gastric cancer (GC) (A). In vitro, cells were incubated with human recombinant HMGB1 (hrHMGB1) for 24 h, and the cultured medium was then used to determine the VEGF-C concentration. VEGF-C secretion was not significantly upregulated by HMGB1 in a dose-dependent manner in GES-1 cells (B),but was in GC cells (C).