Table 2 Statistical results of relationships between claudin-4 expression and various clinicopathologic characteristics
From: Clinicopathological significance of claudin-4 in gastric carcinoma
Variable | Total patients(%) | Patients with low claudin-4 expression (%) | Patients with high claudin-4expression (%) | P- value |
|---|---|---|---|---|
| Â | 329 | 154(46.8) | 175(53.2) | Â |
Age at surgery,y | Â | Â | Â | 0.025 |
≤ 60 | 192 | 100(52.1) | 92(47.9) |  |
> 60 | 137 | 54(39.4) | 83(60.6) |  |
Gender | Â | Â | Â | 0.003 |
Male | 238 | 99(41.6) | 139(58.4) | Â |
Female | 91 | 55(60.4) | 36(39.6) | Â |
Pathophysiologic features | Â | Â | Â | Â |
Tumor size (cm) | Â | Â | Â | 0.055 |
≤ 5 | 199 | 102(51.3) | 97(48.7) |  |
>5 | 130 | 52(40.0) | 78(60.0) | Â |
Tumor location | Â | Â | Â | 0.033 |
Upper | 31 | 9(29.0) | 22(71.0) | Â |
Middle | 53 | 31(58.5) | 22(41.5) | Â |
Lower | 245 | 114(46.5) | 131(53.5) | Â |
Histological type | Â | Â | Â | <0.001 |
Differentiated (WD,MD) | 101 | 24(23.8) | 77(76.2) | Â |
Undifferentiated (PD,UD) | 228 | 130(57.0) | 98(43.0) | Â |
Growth pattern | Â | Â | Â | <0.001 |
Expanding | 76 | 23(30.3) | 53(69.7) | Â |
Intermediate | 81 | 22(27.2) | 59(72.8) | Â |
Infiltrative | 172 | 109(63.4) | 63(36.6) | Â |
T stage | Â | Â | Â | 0.147 |
T1/2 | 96 | 51(53.1) | 45(46.9) | Â |
T3/4 | 233 | 103(44.2) | 130(55.8) | Â |
Lymph node metastasis | Â | Â | Â | 0.905 |
Negative | 101 | 48(47.5) | 53(52.5) | Â |
Positive | 228 | 106(46.5) | 122(53.5) | Â |
Lymphatic invasion | Â | Â | Â | 0.898 |
Negative | 248 | 117(47.2) | 131(52.8) | Â |
Positive | 81 | 37(45.7) | 44(54.3) | Â |
Tumor stage | Â | Â | Â | 0.589 |
IA, IB | 63 | 33(52.4) | 30(47.6) | Â |
IIA, IIB | 86 | 38(44.2) | 48(55.8) | Â |
IIIA, IIIB, IIIC | 180 | 83(46.1) | 97(53.9) | Â |