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Table 4 The 5-year overall survival Cox proportional multivariate hazards model

From: Does geography influence the treatment and outcomes of colorectal cancer? A population-based analysis

Variable Event (n (%)) Adjusted HRa 95%CI P value
Age quartileb     <0.0001
  Quartile 1 210 (38.75) 1   
  Quartile 2 234 (44.83) 1.21 1.00 to 1.46  
  Quartile 3 266 (50.19) 1.59 1.31 to 1.93  
  Quartile 4 328 (66.67) 2.07 1.69 to 2.53  
Gender     0.007
  Female 470 (48.81) 1   
  Male 568 (50.58) 1.19 1.05 to 1.35  
Site     0.755
  Colon 707 (51.38) 1   
  Rectosigmoid 103 (50.99) 1.06 0.85 to 1.31  
  Rectum 228 (44.88) 0.96 0.81 to 1.15  
AJCC stage     <0.0001
  I 111 (27.54) 1   
  II 188 (32.70) 1.44 1.12 to 1.86  
  III 279 (45.74) 2.22 1.71 to 2.87  
  IV 412 (93.85) 7.67 5.88 to 10.00  
  Unknown/NAc 48 (81.36) 3.08 2.14 to 4.45  
Income quintiled     0.004
  Quintile 1 271 (58.66) 1   
  Quintile 2 240 (52.86) 1.07 0.90 to 1.28  
  Quintile 3 209 (47.83) 0.95 0.79 to 1.14  
  Quintile 4 159 (42.51) 0.92 0.75 to 1.13  
  Quintile 5 137 (40.90) 0.77 0.63 to 0.95  
  NF 22 (91.67) 1.78 1.14 to 2.78  
CCI group     <0.0001
  CCI count <1 235 (28.08) 1   
  CCI count = 1 448 (58.56) 2.03 1.70 to 2.42  
  CCI count >1 355 (73.35) 2.79 2.33 to 3.36  
RHA group     0.314
  Winnipeg 589 (48.84) 1   
  North Manitoba 36 (55.38) 0.98 0.69 to 1.39  
  South Manitoba 239 (48.19) 1.16 0.99 to 1.35  
  Middle Manitoba 174 (54.55) 1.04 0.87 to 1.23  
Surgery     <0.0001
  Major surgery 694 (42.63) 0.54 0.40 to 0.73  
  Local resection 14 (24.14) 0.33 0.18 to 0.58  
  Polypectomy 26 (37.14) 0.63 0.40 to 0.97  
  None 304 (92.12) 1   
Chemotherapy     <0.0001
  No 677 (50.52) 1   
  Yes 361 (48.39) 0.59 0.50 to 0.69  
Radiation therapy     0.126
  No 916 (51.29) 1   
  Yes 122 (40.67) 0.84 0.67 to 1.05  
Lymph nodes removed     <0.0001
  0 to 12 249 (47.43) 1   
  >12 440 (39.43) 0.76 0.65 to 0.89  
  Unknown/not examinede 349 (78.43) 1.43 1.06 to 1.94  
  1. All variables listed are included in the full model. aHR >1 relates to higher mortality; bquartile 1: age 20 years to 61 years, quartile 2: age greater than 61 years to 72 years, quartile 3: age greater than 72 years to 80 years, and quartile 4: age greater than 80 years to 103 years; cone or more elements of the AJCC stage is missing or staging scheme is NA; dquintile 1: poorest, quintile 5: richest; eunknown number or no lymph nodes examined. AJCC American Joint Committee on Cancer, CCI Charlson comorbidity index, CI confidence interval, HR hazards ratio, NA not applicable, NF not formatted, RHA regional health authority.