Figure 1

Histopathological evaluation. Hematoxylin and eosin (HE) histologic analysis revealed a highly cellular malignant tumour with solid clusters of atypical, polymorphic epithelial cells (image A, high-power photomicrograph, original magnification, ×400; HE stain). The tumour was partially necrotic (image B, low-power photomicrograph, original magnification, ×100; HE stain). Immunohistochemical study shows that the tumour cells stained positive for estrogene receptors (ER) (image C, low-power photomicrograph, original magnification, ×200) and HER-2/neu receptors (image D, low-power photomicrograph, original magnification, ×200) consistent with diagnosis of breast adenocarcinoma.