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Table 1 The relationship between clinicopathological variables and CK19 expression in hepatocellular carcinoma

From: The expression of cytokeratin 19 in lymph nodes was a poor prognostic factor for hepatocellular carcinoma after hepatic resection

 

Hepatocellular carcinoma, n = 42

 

   CK19 liver a

 

  CK19 lymph node b

 

Negative

Positive (%)

P value

Negative

Positive (%)

P value

Age (yr)

      

   60

24

5 (17.2)

0.275

26

3 (10.3)

0.497

   >60

9

4 (30.8)

 

11

2 (15.4)

 

Gender

      

   Male

26

8 (23.5)

0.443

30

4 (11.8)

0.673

   Female

7

1 (12.5)

 

7

1 (12.5)

 

Hepatitis B virus

      

   Positive

24

4 (14.3)

0.117

26

2 (7.1)

0.197

   Negative

9

5 (35.7)

 

11

3 (21.4)

 

Hepatitis C virus

      

   Positive

7

2 (22.2)

0.633

8

1 (11.1)

0.712

   Negative

26

7 (21.2)

 

29

4 (12.1)

 

Total bilirubin(mg/dl) c

1.348 ± 2.373

0.844 ± 0.335

0.533

1.303 ± 2.236

0.760 ± 0.270

0.595

Alkaline phosphotase (U/L) c

111.4 ± 70.447

93.86 ± 30.905

0.527

111.63 ± 68.54

85.40 ± 26.444

0.408

Preoperative α-fetoprotein (ng/ml) c

8300 ± 39207

669.42 ± 1258

0.589

7594 ± 37510

1033 ± 1525

0.701

Child-Pugh classification

      

   A

32

9 (21.9)

0.786

36

5 (12.2)

0.881

   B

1

0 (0)

 

1

0 (0)

 

Size (cm)

9.027 ± 5.2192

6.156 ± 3.0121

0.124

8.519 ± 5.1876

7.620 ± 2.7472

0.708

T stage

      

   T1/T2

13

5 (27.8)

0.524

16

2 (11.1)

0.688

   T3/T4

20

4 (16.7)

 

21

3 (12.5)

 

N stage

      

   N0

24

2 (7.7)

0.005

26

0 (0)

0.002

   N1

9

7 (43.8)

 

11

5 (31.3)

 

Encapsulation

      

   Yes

19

1 (5)

0.013

19

1 (5)

0.203

   No

14

8 (36.4)

 

18

4 (18.2)

 

Tumor rupture

      

   Yes

4

0 (0)

0.366

4

0 (0)

0.590

   No

29

9 (23.4)

 

33

5 (13.2)

 

Vascular invasion

      

   Yes

12

4 (25)

0.471

12

4 (25)

0.061

   No

21

5 (19.2)

 

25

1 (3.8)

 

Daughter nodules

      

   Yes

13

3 (18.75)

0.529

15

1 (6.25)

0.359

   No

20

6 (23.07)

 

22

4 (15.4)

 

Resection margin

      

   Positive

4

1 (20)

0.606

5

0 (0)

0.284

   Negative

29

8 (21.6)

 

32

5 (13.5)

 

Edmonson and Steiner grade

      

   I/II

15

4 (21.1)

0.180

18

1 (5.3)

0.341

   III/IV

18

5 (21.7)

 

19

4 (17.4)

 
  1. a Immunohistochemical staining of primary liver tumor specimen for CK19.
  2. b Immunohistochemical staining of lymph nodes specimen for CK19.
  3. cData are presented as mean±standard deviation.