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Table 2 Multivariate analysis of clinical and pathologic features in relation to nature of surgery, gender, age group, tumor location, and family history a

From: Clinicopathological analysis of colorectal cancer: a comparison between emergency and elective surgical cases

  >1 tumor (yes vs. no) Tumor diam.
(mm)
Differentiation (poor vs. other)b Mucin type (signet-ring component vs. extracellular) Crohn-like reaction (yes vs. no) TILs (>30/HPF vs. ≤30/10 HPF) Desmoplasia (yes vs. no) Necrosis (yes vs. no) Vascular (yes vs. no) Perineural (yes vs. no) Medullary type (yes vs. no) Budding (yes vs. no) Tumor margin (infiltrative vs. circumscribed)
Type of surgery              
 Elective, n = 845  RC 46.89 RC RC RC RC RC RC
 Emergency, n = 129 3.154 −3.7 3.136 0.375 1.932 2.086 2.500 2.452
P <0.0001c 0.11 0.001c 0.001c 0.04c 0.001c <0.0001c <0.0001c
Gender              
 Male RC
 Female             1.417
P 0.03c
Age group              
 >75 years RC 47.85 RC
 60 to 75 years  0.732 0.59 1.123
P 0.28 0.73 0.46
 <60 years NPCd 5.69            1.928
P   0.009c 0.001
Localization              
 Right colon 56.42 RC RC RC RC RC RC
 Left colon   −12.67 0.224   0.587 0.278     1.005 0.114   1.119
P <0.0001c <0.0001c 0.005c <0.0001c 0.98 <0.0001c 0.51
 Rectum   −18.53 0.302   0.123 0.168     1.812 NPCd   2.902
P <0.0001c <0.0001c <0.0001c <0.0001c NDe NDe 0.005c   NDe <0.0001c
Family history              
 Sporadic
 Familial        2.028     0.318   
P 0.03c 0.03c
Nagelkerke R2f 0.103 0.099 0.083 0.048 0.223 0.140 0.028 0.020 0.034 0.233 0.010 0.101
  1. AJCC American Joint Committee on Cancer, HPF high-power field, N node, NPC not possible to calculate, ND not done, RC reference category, T tumor, TILs tumor-infiltrating lymphocytes.
  2. aData are presented as odds ratios for all features except tumor diameter, for which mean diameter and difference b (mm) are stated.
  3. bIn major tumor component.
  4. cSignificant.
  5. dIt was not possible to calculate odds ratio because there were no multiple tumors in the <60 years age group and only one rectal cancer with medullary features.
  6. eRectal cancers were omitted from the analysis of necrosis, desmoplasia and budding because of preoperative radiotherapy.
  7. fOr adjusted R2.