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Table 2 Multivariate analysis of clinical and pathologic features in relation to nature of surgery, gender, age group, tumor location, and family history a

From: Clinicopathological analysis of colorectal cancer: a comparison between emergency and elective surgical cases

 

>1 tumor (yes vs. no)

Tumor diam.

(mm)

Differentiation (poor vs. other)b

Mucin type (signet-ring component vs. extracellular)

Crohn-like reaction (yes vs. no)

TILs (>30/HPF vs. ≤30/10 HPF)

Desmoplasia (yes vs. no)

Necrosis (yes vs. no)

Vascular (yes vs. no)

Perineural (yes vs. no)

Medullary type (yes vs. no)

Budding (yes vs. no)

Tumor margin (infiltrative vs. circumscribed)

Type of surgery

             

 Elective, n = 845 

RC

46.89

–

RC

–

RC

RC

–

RC

RC

–

–

RC

 Emergency, n = 129

3.154

−3.7

–

3.136

–

0.375

1.932

–

2.086

2.500

–

–

2.452

 P

<0.0001c

0.11

–

0.001c

–

0.001c

0.04c

–

0.001c

<0.0001c

–

–

<0.0001c

Gender

             

 Male

–

–

–

–

–

–

–

–

–

–

–

RC

–

 Female

           

1.417

–

 P

–

–

–

–

–

–

–

–

–

–

–

0.03c

–

Age group

             

 >75 years

RC

47.85

–

–

–

–

–

–

–

–

–

–

RC

 60 to 75 years 

0.732

0.59

–

–

–

–

–

–

–

–

–

–

1.123

 P

0.28

0.73

–

–

–

–

–

–

–

–

–

–

0.46

 <60 years

NPCd

5.69

          

1.928

 P

 

0.009c

–

–

–

–

–

–

–

–

–

–

0.001

Localization

             

 Right colon

–

56.42

RC

–

RC

RC

–

–

–

RC

RC

–

RC

 Left colon

 

−12.67

0.224

 

0.587

0.278

   

1.005

0.114

 

1.119

 P

–

<0.0001c

<0.0001c

–

0.005c

<0.0001c

–

–

–

0.98

<0.0001c

–

0.51

 Rectum

 

−18.53

0.302

 

0.123

0.168

   

1.812

NPCd

 

2.902

 P

–

<0.0001c

<0.0001c

–

<0.0001c

<0.0001c

NDe

NDe

–

0.005c

 

NDe

<0.0001c

Family history

             

 Sporadic

–

–

–

–

–

–

–

–

–

–

–

–

–

 Familial

      

2.028

   

0.318

  

 P

–

–

–

–

–

–

0.03c

–

–

–

0.03c

–

–

Nagelkerke R2f

0.103

0.099

0.083

0.048

0.223

0.140

0.028

–

0.020

0.034

0.233

0.010

0.101

  1. AJCC American Joint Committee on Cancer, HPF high-power field, N node, NPC not possible to calculate, ND not done, RC reference category, T tumor, TILs tumor-infiltrating lymphocytes.
  2. aData are presented as odds ratios for all features except tumor diameter, for which mean diameter and difference b (mm) are stated.
  3. bIn major tumor component.
  4. cSignificant.
  5. dIt was not possible to calculate odds ratio because there were no multiple tumors in the <60 years age group and only one rectal cancer with medullary features.
  6. eRectal cancers were omitted from the analysis of necrosis, desmoplasia and budding because of preoperative radiotherapy.
  7. fOr adjusted R2.
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World Journal of Surgical Oncology

ISSN: 1477-7819

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