From: Postoperative outcomes following pancreaticoduodenectomy: how should age affect clinical practice?
Parameter | Young | Older | P value |
---|---|---|---|
n = 1051 | n = 994 | ||
Male | 552 (52.5) | 518 (52.1) | 0.853 |
White race | 812 (77.3) | 834 (83.9) | <0.001 |
Totally or partially dependent in functional status | 23 (2.2) | 39 (3.9) | 0.022 |
ASA classificationa | <0.001 | ||
I or II | 378 (36.0) | 234 (23.5) | |
III | 640 (60.9) | 688 (69.2) | |
IV or V | 33 (3.1) | 72 (7.2) | |
BMI ≥30 kg/m2 | 303 (28.8) | 210 (21.1) | <0.001 |
Diabetic on oral agents or insulin | 213 (20.3) | 262 (26.4) | 0.001 |
Alcohol intake in two weeks prior (>2 drinks/day) | 46 (4.4) | 28 (2.8) | 0.059 |
Hypertension requiring medication | 412 (39.2) | 655 (65.9) | <0.001 |
Dyspnea on moderate exertion/at rest | 72 (6.9) | 107 (10.8) | 0.002 |
Congestive heart failure in 30 days prior | 2 (0.2) | 5 (0.5) | 0.226 |
Angina in 30 days prior | 3 (0.3) | 7 (0.7) | 0.175 |
Myocardial infarction in 6 months prior | 4 (0.4) | 3 (0.3) | 0.760 |
Previous percutaneous coronary intervention | 50 (4.8) | 98 (9.9) | <0.001 |
Previous cardiac surgery | 30 (2.9) | 93 (9.4) | <0.001 |
History of peripheral vascular diseaseb | 9 (0.9) | 21 (2.1) | 0.018 |
Current smoker (within 1 year) | 348 (33.1) | 140 (14.1) | <0.001 |
History of severe COPD | 42 (4.0) | 77 (7.7) | <0.001 |
History of transient ischemic attack | 8 (0.8) | 42 (4.2) | <0.001 |
History of CVA without neuro deficit | 18 (1.7) | 26 (2.6) | 0.160 |
History of CVA with neuro deficit | 12 (1.1) | 21 (2.1) | 0.082 |
Anemiac | 433 (41.2) | 511 (51.4) | <0.001 |
Bleeding disorder | 24 (2.3) | 36 (3.6) | 0.073 |
Weight loss >10% in 6 months prior | 217 (20.6) | 190 (19.1) | 0.386 |
Disseminated cancer | 32 (3.0) | 26 (2.6) | 0.559 |
Tumor involving central nervous system | 2 (0.2) | 0 (0.0) | 0.169 |
Chemotherapy in 30 days prior | 28 (2.7) | 15 (1.5) | 0.069 |
Radiotherapy in 90 days prior | 37 (3.5) | 31 (3.1) | 0.613 |
Ascites in 30 days prior | 3 (0.3) | 6 (0.6) | 0.277 |
Esophageal varices in 6 months prior | 1 (0.1) | 0 (0.0) | 0.331 |
Currently on dialysis | 3 (0.3) | 5 (0.5) | 0.431 |
Prior operation within 30 days | 16 (1.5) | 24 (2.4) | 0.145 |
Infected surgical wound class | 15 (1.4) | 19 (1.9) | 0.392 |
Total operation time, min (mean ± SD) | 398.9 ± 145.3 | 369.6 ± 125.1 | <0.001 |
Intraoperative pRBC units transfused | 0.001 | ||
0 | 738 (70.2) | 620 (62.4) | |
1 or 2 | 193 (18.4) | 234 (23.5) | |
≥3 | 120 (11.4) | 140 (14.1) |