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Table 1 Clinicopathological features of metaplastic breast carcinoma, invasive ductal carcinoma and triple-negative invasive ductal carcinoma

From: Unique clinicopathological features of metaplastic breast carcinoma compared with invasive ductal carcinoma and poor prognostic indicators

  Metaplastic breast cancer (N = 55) Invasive ductal carcinoma (N = 767) TN-IDC (N = 131)
Features N (%) N (%) P N (%) P
Age    0.594   0.264
  ≤50 27 (49.09) 405 (52.80)   76 (58.02)  
  >50 28 (50.91) 362 (47.20)   55 (41.98)  
Stage    0.001   <0.001
  I 4 (7.27) 107 (13.95)   21 (16.03)  
  II 30 (54.55) 522 (68.06)   92 (70.23)  
  III 16 (29.09) 87 (11.34)   8 (6.11)  
  Unknown 5 (9.09) 51 (6.65)   10 (7.63)  
Operation    0.051   0.054
  Breast-conserving surgery 4 (7.27) 134 (17.47)   25 (19.08)  
  Modified radical mastectomy 51 (92.73) 633 (82.53)   106 (80.92)  
Chemotherapy    0.302   0.295
  Yes 48 (87.28) 627 (81.74)   106 (80.91)  
  No 7 (12.73) 140 (18.25)   25 (19.08)  
Radiotherapy    <0.001   <0.001
  Yes 27 (49.09) 177 (23.08)   29 (22.14)  
  No 28 (50.91) 590 (76.92)   102 (77.86)  
Hormone therapy    <0.001   
  Yes 13 (23.64) 522 (68.06)   
  No 42 (76.46) 245 (31.94)   
Pathological tumor stage    <0.001   <0.001
  T1 (≤2 cm) 5 (9.09) 317 (41.33)   58 (44.27)  
  T2 (2–5 cm) 22 (40.00) 332 (43.29)   55 (41.98)  
  T3 (>5 cm) 22 (40.00) 39 (5.08)   5 (3.82)  
  Tx 6 (10.91) 79 (10.30)   13 (9.92)  
Pathological nodal stage    0.001   0.001
  N0 35 (63.64) 314 (41.20)   50 (38.17)  
  N1-3 15 (27.27) 385 (49.93)   69 (52.67)  
  Nx 5 (9.09) 68 (8.87)   12 (9.16)  
Histological grade    0.167   0.285
  I or II 29 (52.73) 461 (60.10)   77 (58.78)  
  III 20 (36.36) 227 (29.60)   41 (31.30)  
  Unknown 6 (10.91) 79 (10.30)   13 (9.92)  
Ki-67 a    <0.001   <0.001
  ≥14% 47 (87.27) 486 (63.36)   80 (61.07)  
  <14% 8 (12.73) 281 (36.64)   51 (38.93)  
P53 b    0.001   0.008
  ≥25% 28 (50.91) 221 (28.81)   40 (30.53)  
  <25% 27 (49.09) 546 (71.19)   91 (69.47)  
Estrogen receptor    <0.001   
  + 8 (14.55) 419 (54.63)   
  − 47 (85.45) 348 (45.37)   
Progesterone receptor    <0.001   
  + 10 (18.18) 492 (64.14)   
  − 45 (81.82) 276 (35.98)   
Human epidermal growth factor receptor-2    0.005   
  + 9 (16.36) 268 (34.94)   
  − 46 (83.64) 499 (65.06)   
TN-MBC 37 (67.27) 131 (18.22) <0.001  
Not TN-MBC 18 (32.73) 636 (81.78)   
  1. aMedian value for Ki-67 = 13.96, bMedian value for P53 = 24.85. TN-MBC, triple-negative metaplastic breast carcinoma; TN-IDC, triple-negative invasive ductal carcinoma.