Figure 2From: Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expressionHCPT induces apoptosis in colon cancer cells. SW1116 (A) and Colo 205 (B) were treated with 10-hydroxycamptothecin (HCPT) (2.5 μg/mL) at the indicated time. Apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining. The data represent the means ± SD from three independent experiments; *P < 0.01, compared to the PBS group. (C) SW1116 and Colo 205 were treated with HCPT (2.5 μg/mL) at the indicated dose for 48 hours. Apoptosis was determined by TUNEL staining. The data represent the means ± SD from three independent experiments; *P < 0.01, compared to PBS treatment.Back to article page