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Table 2 Diverse actions of NO in cancer: tumoricidal role of NO

From: Nitric oxide and cancer: a review

Tumoricidal role

Role of NO

Mechanism by which NO acts

Cytostatic and\or cytotoxic effect on tumor cells

NO suppresses cellular respiration and also shifts iron metabolism

Suppression of DNA synthesis

Proapoptotic modulator by activating caspase family proteases, upregulation of p53, alteration in expression of apoptosis-associated proteins