Prognostic predictive values of gemcitabine sensitivity-related gene products for unresectable or recurrent biliary tract cancer treated with gemcitabine alone

Table 5 Multivariate analysis for overall survival using variables including hENT1 and RRM1

Variable	Comparison	HR	95% CI	P value
Primary tumor site	Gallbladder vs. extrahepatic bile duct	2.136	0.751 to 6.078	0.155
Recurrence or unresectable	Unresectable vs. recurrence	3.109	0.860 to 11.238	0.084
Histological type	Poor vs. well/moderately	0.732	0.235 to 2.282	0.591
hENT1 expression	High vs. low	0.220	0.077 to 0.629	0.005
RRM1 expression	High vs. low	2.315	0.773 to 6.928	0.133

CI, confidence interval; hENT1, human equilibrative nucleoside transporter; HR, hazard ratio; RRM1, ribonucleotide reductase subunit M1.

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