Abbreviation
|
Drug
|
Mechanism of action
|
Starting concentration (μM)
|
ppc (μM)
|
---|
CIS
|
cisplatin
|
DNA synthesis inhibition
|
1.67 × 10
|
8.33
|
5FU
|
5-fluorouracil
|
Antimetabolite
|
3.84 × 103
|
1.17 × 102
|
CPT
|
irinotecan
|
Topoisomerase I inhibition
|
2.95 × 102
|
N.D.
|
SN38
|
SN-38
|
Topoisomerase I inhibition
|
1.02 × 102
|
5.10 × 10-2
|
DTX
|
docetaxel
|
Microtubule inhibition
|
1.16 × 102
|
2.32
|
PXL
|
paclitaxel
|
Microtubule inhibition
|
7.03 × 10
|
5.86
|
MTX
|
methotrexate
|
Antimetabolite
|
5.50 × 10
|
3.30 × 10
|
DXR
|
doxorubicin
|
DNA synthesis inhibition
|
1.72 × 102
|
0.62
|
EPI
|
epirubicin
|
DNA synthesis inhibition
|
1.72 × 102
|
1.72 × 10
|
EPS
|
etoposide
|
Topoisomerase II inhibition
|
3.40 × 102
|
1.69 × 10
|
GEM
|
gemcitabine
|
Antimetabolite
|
3.34 × 103
|
7.34 × 10
|
OXP
|
oxaliplatin
|
DNA synthesis inhibition
|
1.26 × 102
|
2.27
|
VIN
|
vinorelbin
|
Microtubule inhibition
|
9.3 × 10
|
0.93
|
LEU
|
leucovorin
|
Anti metabolite
|
5.9 × 10
|
6.84
|
- N.D., not determined; ppc, peak plasma concentration.