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Table 2 Drugs used in chemosensitivity tests

From: Evaluation of chemosensitivity prediction using quantitative dose–response curve classification for highly advanced/relapsed gastric cancer

Abbreviation Drug Mechanism of action Starting concentration (μM) ppc (μM)
CIS cisplatin DNA synthesis inhibition 1.67 × 10 8.33
5FU 5-fluorouracil Antimetabolite 3.84 × 103 1.17 × 102
CPT irinotecan Topoisomerase I inhibition 2.95 × 102 N.D.
SN38 SN-38 Topoisomerase I inhibition 1.02 × 102 5.10 × 10-2
DTX docetaxel Microtubule inhibition 1.16 × 102 2.32
PXL paclitaxel Microtubule inhibition 7.03 × 10 5.86
MTX methotrexate Antimetabolite 5.50 × 10 3.30 × 10
DXR doxorubicin DNA synthesis inhibition 1.72 × 102 0.62
EPI epirubicin DNA synthesis inhibition 1.72 × 102 1.72 × 10
EPS etoposide Topoisomerase II inhibition 3.40 × 102 1.69 × 10
GEM gemcitabine Antimetabolite 3.34 × 103 7.34 × 10
OXP oxaliplatin DNA synthesis inhibition 1.26 × 102 2.27
VIN vinorelbin Microtubule inhibition 9.3 × 10 0.93
LEU leucovorin Anti metabolite 5.9 × 10 6.84
  1. N.D., not determined; ppc, peak plasma concentration.