Evaluation of chemosensitivity prediction using quantitative dose–response curve classification for highly advanced/relapsed gastric cancer

Table 2 Drugs used in chemosensitivity tests

Abbreviation	Drug	Mechanism of action	Starting concentration (μM)	ppc (μM)
CIS	cisplatin	DNA synthesis inhibition	1.67 × 10	8.33
5FU	5-fluorouracil	Antimetabolite	3.84 × 10³	1.17 × 10²
CPT	irinotecan	Topoisomerase I inhibition	2.95 × 10²	N.D.
SN38	SN-38	Topoisomerase I inhibition	1.02 × 10²	5.10 × 10^-2
DTX	docetaxel	Microtubule inhibition	1.16 × 10²	2.32
PXL	paclitaxel	Microtubule inhibition	7.03 × 10	5.86
MTX	methotrexate	Antimetabolite	5.50 × 10	3.30 × 10
DXR	doxorubicin	DNA synthesis inhibition	1.72 × 10²	0.62
EPI	epirubicin	DNA synthesis inhibition	1.72 × 10²	1.72 × 10
EPS	etoposide	Topoisomerase II inhibition	3.40 × 10²	1.69 × 10
GEM	gemcitabine	Antimetabolite	3.34 × 10³	7.34 × 10
OXP	oxaliplatin	DNA synthesis inhibition	1.26 × 10²	2.27
VIN	vinorelbin	Microtubule inhibition	9.3 × 10	0.93
LEU	leucovorin	Anti metabolite	5.9 × 10	6.84

ISSN: 1477-7819