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Table 3 Univariate and multivariate analysis of prognostic indicators on cancer-specific survival for colorectal cancer patients

From: The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer

Parameters

Number

Univariate analysis Hazard ratio (95% CI)

P value

Multivariate analysis Hazard ratio (95% CI)

P value

DM (yes/no)

283/912

0.91(0.72-1.17)

.463

0.83(0.61-1.23)

0.234

Age (≥65/<65)years

632/565

1.19(0.97-1.46)

.092

1.27(0.97-1.67)

0.083

Sex (Male/Female)

674/523

1.08(0.88-1.32)

.467

1.05(0.81-1.37)

0.692

Location (Rectum/Colon)

369/828

0.81(0.64-1.00)

.058

0.82(0.62-1.09)

0.176

Tumor size (≥5/<5)cm

518/679

1.42(1.15-1.74)

< .001

1.13(0.86-1.47)

0.384

BMIa (<22/≥22) kg/M2

394/803

1.43(1.16-1.77)

< .001

1.16(0.88-1.51)

0.301

Albumin (<3.5/≥3.5)gm/dl

476/721

1.79(1.44-2.23)

< .001

1.40(1.08-1.82)

0.011

Histology (PD/MD + WDb)

135/1062

1.89(1.42-2.52)

< .001

1.35(.094-1.94)

0.124

AJCCc stage (III&IV/I&II)

565/632

3.95(3.15-4.96)

< .001

2.22(1.65-2.99)

< 0.001

Pre-op CEAd (≥5/<5) ng/ml

559/638

2.98(2.38-3.73)

< .001

1.25(0.91-1.73)

0.225

Post-op CEAd (≥5/<5) ng/ml

338/859

5.47(4.39-6.81)

< .001

3.71(2.84-4.83)

< 0.001

Vascular invasion (yes/no)

395/802

2.97(2.40-3.67)

< .001

1.54(1.18-2.01)

0.002

Perineurial invasion (yes/no)

447/750

2.51(2.03-3.10)

< .001

1.82(1.40-2.37)

< 0.001

  1. a BMI Body mass index.
  2. b PD Poorly differentiated, MD Moderately differentiated, WD Well differentiated.
  3. c AJCC American Joint Commission on Cancer.
  4. d CEA Carcinoembryonic antigen.