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Figure 3 | World Journal of Surgical Oncology

Figure 3

From: Three uncommon adrenal incidentalomas: a 13-year surgical pathology review

Figure 3

Primary adrenal pleomorphic leiomyosarcoma. (A) Photomicrograph of hematoxylin and eosin (H&E)-stained slide at low magnification shows a well demarcated neoplastic lesion (*) separated by a pseudocapsule (arrows) from the adjacent normal, uninvolved renal parenchyma (^). (B) Photomicrograph of H&E-stained slide at high magnification shows the tumor cells to be composed of sheaths of pleomorphic cells with marked cytological atypia including large bizarre cells with irregular nuclei and prominent nucleoli. (C) Photomicrograph of H&E-stained slide at moderate magnification shows areas of focal necrosis (*) and perineural invasion (arrow). (D) Photomicrograph of H&E-stained slide at moderate magnification shows sheets of neoplastic spindle cells in a prominent storiform pattern. (E) Photomicrograph of H&E-stained slide at moderate magnification demonstrates heterogeneity of the tumor cells in a marked myxoid (*) background. (F) Photomicrograph of immunohistochemically-stained slide with smooth muscle actin (SMA) at low magnification shows strong expression within the lesional cells.

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