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Table 1 Lists of previously reported thyroid T-cell lymphoma

From: Problems of primary T-cell lymphoma of the thyroid gland -A case report

References*

Age/gender

Presentation

Chronic thyroiditis

HTLV-1

Histology

Molecular Diagnosis

Diagnostic intervention

Therapy

prognosis

[3] 1977

73/F

 

N/A

N/A

   

S + R

alive at 24 months

[4] 1990

79/M

Goiter

N/A

N/A

Diffuse small cleaved

 

open biopsy

C + R

alive at 4 years

[4] 1990

80/F

Goiter

(+)

N/A

Diffuse small cleaved

 

Hemithyroidectomy

S

DUC

[5] 1996

64/F

Thyroid mass, Hypothyroidism

(+)

(-)

CD2+, CD3+, CD5+, CD45RO+

TCR-β, TCR-γ rearrangement

Total thyroidectomy

S + C + R

alive at 9 months

[6] 1997

59/F

Goiter

(+)

(-)

CD3+, CD4-, CD8-, CD19-

TCR-δ rearrangement

Open biopsy

C + R

alive at 22 months

[7] 1999

65/M

Thyroid mass, Horseness, dyspasia,

(-)

N/A

CD45RO+, CD45-, vimentin+

 

Open biopsy

C + R

died at 11 months

[8] 1999

39/F

Goiter, fever, dysphonia

(+)

N/A

CD30+, CD45RO+, CD3-, CD20-, CD79a-, CD21-

 

Open biopsy

C + R

alive at 1 year

[9] 2000

63/F

Thyroid mass, Hoarseness, dyspnea

(+)

N/A

CD45RO+, CD43+

 

Total thyroidectomy

S + C + R

alive at 3 years

[10] 2001

72/M

Thyroid mass, pressure, difficulty swallowing

(+)

N/A

CD4+

 

Right hemithyroidectomy

C + R

alive at 12 months

[11] 2005

71/F

Thyroid swelling, horseness, goiter

(+)

(-)

CD3+, CD45RO+, CD4+

TCR-β, TCR-γ rearrangement

Total thyroidectomy

S

alive at 25 months

[12] 2005

86/F

Swelling of neck

(-)

(-)

CD3e+, CD5+, TIA-1+ (T-cell restricted antigen)

TCR-Cβ rearrangement

Left hemithyroidectomy

S

alive at 2 years

[13] 2007

34/M

N/A

(-)

(-)

CD3+, CD5+, CD7-, CD43+, CD45RO+, CD20-

 

N/A

S + C + R

died at 13 months

[14] 2007

61/M

Thyroid mass

(+)

(-)

CD3+, CD4+,

TCR-β rearrangement

Open biopsy

C

alive at 4 years

[14] 2007

68/M

Thyroid mass, dyspnea

(+)

(-)

CD3+, CD4+, TCR-ab+

 

Open biopsy

C

died at 5 months

[15] 2008

32/M

Swelling of neck, fatigue, shortness of breath

(-)

N/A

CD3+,

TCR-γ rearrangement(PCR)

Open biopsy

C

alive at 1 year

present

70/F

Neck swelling

(+)

(-)

CD3+, CD45RO+,

TCR-β, TCR-γ rearrangement

Total thyroidectomy

S

alive at 20 months

  1. References*, Number in brackets indicate reference numbers and other numbers indicate published year; N/A, not available; C, chemotherapy; DFS, disease-free survival; DUC, died of unrelated cause; IgH, immunoglobulin heavy chain; PCR, polymerase chain reaction; R, radiation therapy; S, surgery; TCR, T-cell receptor.