Table 2 Correlation between combined p53 mutation and p14ARF, DAPK, and/or ASC/TMS1 methylation with pathologic biology in cholangiocarcinoma
| Â | Â | combined p53 mutation and p14ARF, DAPK, and/or ASC/TMS1 methylation | ||
|---|---|---|---|---|
Pathologic character | cases | positive | positive ratio (%) | P-value |
Pathologic type | Â | Â | Â | Â |
   Tubular carcinoma | 18 | 5 | 27.8 |  |
   Papillary carcinoma | 9 | 1 | 11.1 |  |
   Mucoid carcinoma | 4 | 4 | 100.0 |  |
   Non-differentiated | 5 | 4 | 80.0 | < 0.05 |
   carcinoma |  |  |  |  |
Differentiation | Â | Â | Â | Â |
   Well -Moderate | 25 | 6 | 24.0 |  |
   Poor | 11 | 8 | 72.7 | < 0.05 |
Invasion | Â | Â | Â | Â |
   T1 | 16 | 2 | 12.5 |  |
   T2 | 10 | 4 | 40.0 |  |
   T3 | 10 | 8 | 80.0 | < 0.05 |
Lymph node metastasis | Â | Â | Â | Â |
   N0 | 3 | 0 | 0 |  |
   N1 | 33 | 14 | 42.4 | > 0.05 |