Table 2 The associations between cyclin D1 overexpression and clinicopathological parameters (N = 264)
From: Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma
| Â | Cyclin D1 protein overexpression | Â | |
|---|---|---|---|
| Â | No [N (%)] | Yes [N (%)] | p value |
Age | Â | Â | Â |
   < 50 yrs (n = 151) | 93 (61.6) | 58 (38.4) | 0.516 |
   ≥ 50 yrs (n = 113) | 74 (65.5) | 39 (34.5) |  |
Subsites | Â | Â | Â |
   Tongue (n = 100) | 52 (52.0) | 48 (48.0) | 0.007 |
   Bucca (n = 106) | 81 (76.4) | 25 (23.6) |  |
   Others (n = 58) | 34 (58.6) | 24 (41.4) |  |
Tumor stage | Â | Â | Â |
   Early (n = 76) | 55 (72.4) | 21 (27.6) | 0.051 |
   Advanced (n = 188) | 112 (59.6) | 76 (40.4) |  |
Primary tumor | Â | Â | Â |
   T1/T2 (n = 129) | 77 (59.7) | 52 (40.3) | 0.240 |
   T3/T4 (n = 135) | 90 (66.7) | 45 (33.3) |  |
Differentiation | Â | Â | Â |
   Well (n = 107) | 76 (71.0) | 31 (29.0) | 0.031 |
   Moderate/poor (n = 157) | 91 (58.0) | 66 (42.0) |  |
Tumor depth | Â | Â | Â |
   < 10 mm (n = 95) | 66 (69.5) | 29 (30.5) | 0.116 |
   ≥ 10 mm (n = 169) | 101 (59.8) | 68 (40.2) |  |
Lymph node metastasis | Â | Â | Â |
   LN (-); ECS (-) (n = 138) | 101 (73.2) | 37 (26.8) | 0.002 |
   LN (+); ECS (-) (n = 55) | 30 (54.5) | 25 (45.5) | 0.001* |
   LN (+); ECS (+) (n = 71) | 36 (50.7) | 35 (49.3) |  |
Skin invasion | Â | Â | Â |
   Yes (n = 28) | 22 (78.6) | 6 (21.4) | 0.075 |
   No (n = 236) | 145 (61.4) | 91 (38.6) |  |
Bone invasion | Â | Â | Â |
   Yes (n = 67) | 42 (62.7) | 25 (37.3) | 0.911 |
   No (n = 197) | 125 (63.5) | 72 (36.5) |  |
Perineural invasion | Â | Â | Â |
   Yes (n = 72) | 39 (54.2) | 33 (45.8) | 0.061 |
   No (n = 192) | 128 (66.7) | 64 (33.3) |  |
AQ chewing | Â | Â | Â |
   Yes (n = 227) | 147 (64.8) | 80 (35.2) | 0.210 |
   No (n = 37) | 20 (54.1) | 17 (45.9) |  |
Cigarette smoking | Â | Â | Â |
   Yes (n = 225) | 147 (65.3) | 78 (34.7) | 0.093 |
   No (n = 39) | 20 (51.3) | 19 (48.7) |  |
Alcohol drinking | Â | Â | Â |
   Yes (n = 133) | 83 (62.4) | 50 (37.6) | 0.772 |
   No (n = 131) | 84 (64.1) | 47 (35.9) |  |