Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer

Table 4 Multivariate analysis for distant recurrence-free survival (DRFS) and overall survival (OS)

			DRFS			OS
	P	HR	95.0% CI	P	HR	95.0% CI
Subtype
Luminal-A	Ref.			Ref.
Luminal-HER2	0.57	1.26	0.55-2.85	0.64	1.23	0.50-2.98
HER2-enriched	0.39	1.52	0.57-4.03	0.01	3.76	1.35-10.49
TNBC	0.69	1.15	0.56-2.36	0.71	1.16	0.50-2.66
Metastatic site
Bone	Ref.			Ref.
Extra-bone (excluding brain)	0.67	0.87	0.46-1.64	0.05	2.05	0.99-4.23
Bone + extra-bone (excluding brain)	0.15	0.53	0.21-1.28	0.75	1.18	0.40-3.45
Brain	0.24	2.63	0.51-13.57	0.03	3.92	1.11-13.80
Brain + extra-brain	0.62	1.38	0.37-5.08	0.51	1.71	0.34-8.57
Tumor size (< 5 cm vs. ≥ 5 cm)	0.96	0.98	0.42-2.28	0.71	0.82	0.30-2.25
Nodal status (N0 vs. ≥ N1)	0.97	0.99	0.54-1.81	0.87	1.06	0.49-2.25
Age (continuous variable)	0.22	1.02	0.98-1.05	0.90	0.99	0.96-1.03

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