Table 3 Multivariate Cox regression analysis of potential prognostic factors for 177 osteosarcoma patients
Clinical characteristics | OS | DFS | ||
|---|---|---|---|---|
Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | |
Histological type | ||||
Osteoblastic | 3.615(1.232,10.603) | 0.019 | 2.653(0.915,7.693) | 0.072 |
Chondroblastic | 2.262(0.673,7.602) | 0.187 | 1.449(0.439,4.781) | 0.543 |
Fibroblastic | 1.670(0.425,6.564) | 0.463 | 1.093(0.285,4.198) | 0.897 |
Dilated blood vessels | 3.506(0.932,13.195) | 0.064 | 3.950(1.061,14.773) | 0.041 |
Others | 1.000 | 1.000 | ||
Tumor size | ||||
< 6 cm | 1.000 | ---- | ---- | |
≥ 6 cm | 1.685(1.071,2.650) | 0.024 | ||
Surgery type | ||||
Amputation | 1.000 | 1.000 | ||
Limb sparing | 0.375(0.247,0.570) | < 0.01 | 0.392(0.257,0.597) | < 0.01 |
Pre-ALP | ||||
Normal | 1.000 | 1.000 | ||
High | 1.461(0.806,2.647) | 0.212 | 1.542(0.847,2.806) | 0.157 |
Very high | 1.979(1.063,3.684) | 0.031 | 2.090(1.135,3.848) | 0.018 |
Lung metastasis | ||||
No | 1.000 | 1.000 | ||
Yes | 2.232(1.395,3.572) | 0.001 | 5.456(3.266,9.114) | < 0.01 |