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Table 1 Correlation between pre-ALP and clinicopathologic characteristics

From: High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China

Clinicopathologic characteristics

Very high pre-ALP

(n= 52)

High pre-ALP

(n= 76)

Normal pre-ALP

(n= 49)

P value

Gender

    

   Male

35

50

32

0.831

   Female

17

26

17

 

Primary location

    

   Humerus

6

2

4

0.005

   Radius

0

1

0

 

   Femur

36

40

17

 

   Tibia

7

28

17

 

   Fibula

3

2

8

 

   Others

0

3

3

 

Histological type

    

   Osteoblastic

40

45

24

< 0.01

   Chondroblastic

8

12

5

 

   Fibroblastic

1

9

6

 

   Dilated blood vessels

3

5

3

 

   Others

0

5

11

 

Tumor size

    

   < 6 cm

14

35

26

0.008

   ≥ 6 cm

38

41

23

 

Surgery type

    

   Amputation

24

35

26

0.268

   Limb sparing

28

41

23

 

Post-operative chemotherapy

    

   No standard a

40

54

20

< 0.01

   Standard b

12

22

29

 

Lung metastasis

    

   Yes

18

16

6

0.007

   No

34

60

43

 

Local recurrence

    

   Yes

4

7

3

0.782

   No

48

69

46

 

Survival status

    

   Alive

14

35

32

< 0.01

   Dead

38

41

17

 
  1. ALP alkaline phosphatase
  2. a post-operative chemotherapy cycles < 8
  3. b post-operative chemotherapy cycles ≥ 8