Table 4 Literature review about the prognosis of HER-2 overexpression or amplification in gastric cancer
Reference | N (total/survival analysis) | % HER-2/neu+ definition | Prognostic factor | |
|---|---|---|---|---|
Univariate analysis/association | Multivariate analysis | |||
[12] | 131/131 | 12.2 (FISH+) | Yes/two groups | Not done |
[15] | 182/182 | 15.9 (IHC 2+ or 3+) | Yes/two groups | No |
Kim MA (2007) [ 18] | 248/96 | 7.7 (FISH+) | Yes/Intestinal type, I stage | Not done |
[13] | 463/256 | 9.3 (FISH+) | Yes/Expansive type | Not done |
[21] | 1414/582 (section), 598/255 (TMA) | 12.3 (section), 17 (TMA) (IHC 2+ or 3+) | Yes/Differentiation (W+M) | No (section)/Yes (TMA) |
[22] | 221/221 | 15 (FISH+) | Yes/two groups | Not done |
[23] | 217/217 | 11 (IHC 3+ ) | Yes/two groups and intestinal type | Not done |
[24] | 1036/1036 | 6.1 (IHC3+ or IHC2+ and FISH+) | No | No |