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Figure 4 | World Journal of Surgical Oncology

Figure 4

From: 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis

Figure 4

RBM5 induces dysfunction of mitochondrial membrane potential and modulates apoptosis of PC-3 cells. (A) Morphological images of PC-3 cells transfected with pcDNA3.1 and pcDNA3.1-RBM5. (B) Analysis of mitochondrial membrane potential by Rhodamine123 staining in PC-3 cells under the fluorescence microscope. (C) Flow cytometry analysis of apoptosis by Annexin V staining. The representative data of FCM with Annexin V and PI staining for detecting apoptotic cells were shown in controls and RBM5-transfected groups. Q1 represents normal cells, Q2 and Q3 represent early and late apoptotic cells, respectively, Q4 represents necrotic cells.

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