Skip to main content

Table 2 Univariate and multivariate analysis of overall survival and recurrence-free survival in patients with renal cell carcinoma

From: High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma

Covariate Univariate analysis Multivariate analysis
OS RFS OS RFS
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
Gender (male vs. female) 0.941 0.862 0.939 0.844 0.887 0.75 0.876 0.705
(0.474, 1.869) (0.504, 1.752) (0.422, 1.861) (0.443, 1.734)
Age (≤60 vs. >60 years) 1.459 0.269 1.043 0.897 1.759 0.141 1.112 0.769
(0.747, 2.850) (0.554, 1.961) (0.829, 3.734) (0.549, 2.251)
Tumor size (≤4 vs. 4–7 vs. >7cm) 1.399 0.145 1.448 0.083 1 0.999 0.898 0.715
(0.890, 2.198) (0.953, 2.199) (0.539, 1.854) (0.503, 1.602)
Symptoms at diagnosis 1.951 0.05 1.605 0.126 2.35 0.04 1.745 0.121
(incidental vs. symptoms) (1.001, 3.800) (0.875, 2.942) (1.038, 5.318) (0.863, 3.527)
AJCC stage (T1 vs. T2 vs. T3-T4) 1.325 0.153 1.351 0.104 0.96 0.881 1.123 0.643
(0.901, 1.950) (0.940, 1.942) (0.565, 1.633) (0.688, 1.831)
Lymph nodal status 1.079 0.725 1.097 0.637 0.997 0.989 0.962 0.861
(N0 vs. N1 vs. Nx) (0.706, 1.649) (0.746, 1.613) (0.613, 1.620) (0.620, 1.490)
Metastasis (M0 vs. M1) 3.389 0.023 4.324 0.003 5.109 0.014 6.807 0.001
(1.187, 9.677) (1.642, 11.391) (1.390, 18.787) (2.103, 22.035)
Histologic variant 1.587 0.339 1.565 0.31 1.486 0.521 2.167 0.157
(clear cell vs. others) (0.615, 4.091) (0.659, 3.715) (0.443, 4.981) (0.734, 6.319)
Fuhrman’s grade 1.363 0.173 1.268 0.26 1.316 0.274 1.105 0.675
(1 vs. 2 vs. 3 vs. 4) (0.873, 2.130) (0.839, 1.918) (0.805, 2.151) (0.693, 1.761)
CXCR4 (low vs. high) 3.994 0.002 3.772 0.001 6.946 <0.001 8.034 <0.001
(1.655, 9.639) (1.741, 8.169) (2.498, 19.314) (3.192, 20.221)
CXCR7 (low vs. high) 4.465 0.013 3.195 0.015 5.506 0.01 6.059 0.001
(1.366, 14.594) (1.254, 8.139) (1.506, 20.129) (2.013, 18.237)
SDF-1 (low vs. high) 3.344 <0.001 3.206 <0.001 11.406 <0.001 14.025 <0.001
  (1.713, 6.527)   (1.734, 5.928)   (4.718, 27.576)   (5.864,33.542)  
  1. OS, overall survival; RFS, recurrence-free survival; HR, hazard rate; CI, confidence interval.