Results of endoscopic examination, postoperative gross specimen and pathologic examination. (a) Endoscopy revealed circular stricture of esophagus at 25 cm from the incisor teeth. (b) Gross specimen of resected esophagus showed a deep, linear, longitudinal and transmural ulceration (20 × 15 mm), which perforated into the mediastinum. All layers of the esophagus were thickened, but the mucosa was smooth. (c) Pathology examination showed chronic inflammation of ulcerative esophagus. HE, 100×. (d) Pathology showed noncaseating granulomatous of the submucosa tissue. HE, 100×. (e) Pathology showed squamous cell proliferation of the esophageal mucosa. HE, 300×.